IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products.

Shin Hye Park, Young Ah Lee, Myeong Heon Shin

Abstract read

In one paragraph

Article in Parasites, hosts and diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Shin Hye ParkDepartment of Tropical Medicine and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea.

Young Ah LeeDepartment of Environmental Medical Biology, Jeju National University College of Medicine, Jeju, Korea.

Myeong Heon ShinDepartment of Tropical Medicine and Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul, Korea.

Funding

National Research Foundation of Korea NRF-2020R1I1A1A01064838Yonsei University College of Medicine 6-2021-0238

6 · The paper itself

Abstract

Trichomonas vaginalis infection causes vaginitis and cervicitis in women, and asymptomatic urethritis and prostatitis in men. Mast cells play a key role in the inflammatory response against T. vaginalis infection. In this study, we examined the signaling pathways involved in mast cell activation induced by T. vaginalis-derived secretory products (TvSP), focusing on IKK2, calcium, MAP kinase (MAPK), and PI3 kinase (PI3K). TvSP stimulation induced phosphorylation and degradation of IκB, indicating NF-κB activation, and triggered phosphorylation of ERK1/2, p38 MAPK, and AKT. TvSP also increased the surface expression of CD63, a marker of exocytosis, which was reduced by IKK inhibition, calcium chelation, or blockade of PI3K and PKC. Furthermore, inhibition of PI3K or MAPKs decreased TvSP-induced interleukin-8 production. These results suggest that IKK2 and calcium are critical for TvSP-induced degranulation, while PI3K and MAPK pathways contribute to interleukin-8 production in mast cells.

Indexed as

CalciumExocytosisI-kappa B KinaseInterleukin-8Mast CellsMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesTrichomonas vaginalisCells, CulturedHumansSignal TransductionTetraspanin 30CalciumI-kappa B KinaseIKBKB protein, humanInterleukin-8Mitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesTetraspanin 30CD63exocytosisIKK2interleukin-8mast cellsTrichomonas vaginalis

Identifiers

PMID41668260

DOI10.3347/PHD.25079

PMCPMC12890562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.