ArticleJournal of cardiothoracic surgery2026
Predictive value of miR-193a-5p combined with VEGFB in the diagnosis and prognosis of CHD.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- MicroRNA-425-5p as a diagnostic biomarker and ox-LDL-induced VSMC regulator in atherosclerosis.Journal of cardiothoracic surgery · 2026Article
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4 authors.
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Abstract
objectivesCoronary heart disease (CHD) stands as a major cause of fatal outcomes, but current diagnostic methods often lack sensitivity or are highly invasive. The synergistic role of miR-193a-5p and VEGFB in CHD remains unclear. This study explores their combined predictive value for CHD diagnosis and prognosis.
methods105 CHD and 70 non-CHD subjects were enrolled. Serum was collected to detect the abundance of miR-193a-5p and VEGFB. The diagnostic efficacy of the two was analyzed by ROC curve. The prognosis was recorded during the follow-up, and risk factors were evaluated of CHD occurrence and prognosis by logistic regression.
resultsIn the serum of CHD patients, the abundance of miR-193a-5p was down-regulated, while VEGFB was up-regulated, and their expressions were significantly correlated. The AUC of miR-193a-5p and VEGFB for individual diagnosis of CHD was 0.9097 and 0.7512, which increased to 0.9415 for combined diagnosis. In the poor prognosis group, miR-193a-5p was lower and VEGFB was higher. The AUC of their combined prediction for poor prognosis was 0.9575, significantly better than individual detection. Logistic regression showed that miR-193a-5p and VEGFB were independent influencing factors for CHD occurrence and poor prognosis.
conclusionmiR-193a-5p combined with VEGFB has high value for the diagnosis and prognostic evaluation of CHD, and is expected to become a new biomarker and potential therapeutic target for precision diagnosis and treatment of CHD.
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