Evidence map›Paper›PMID 41668182›Full record

ArticleTrials2026

Early oral anti-inflammatory diet in patients with mild acute pancreatitis: study protocol for a randomized controlled trial.

Xue Yang, Li Zhang, Hairong Lin, Xin Zeng, Xin Zhou, Jing Liu, Hong Li, Guirong Li

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xue Yang *School of Nursing, Chengdu Medical College, Xindu Street No. 783, Chengdu, 610500, China.ORCID http://orcid.org/0009-0004-0860-5546
Li Zhang *School of Nursing, Chengdu Medical College, Xindu Street No. 783, Chengdu, 610500, China.
Hairong Lin *Department of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No.12 Jingzhong Street, Mianyang, 621000, China.
Xin ZengDepartment of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No.12 Jingzhong Street, Mianyang, 621000, China.
Xin ZhouDepartment of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No.12 Jingzhong Street, Mianyang, 621000, China.
Jing LiuDepartment of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No.12 Jingzhong Street, Mianyang, 621000, China.
Hong LiDepartment of Gastroenterology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No.12 Jingzhong Street, Mianyang, 621000, China. 764811906@qq.com.
Guirong LiNursing Department of Mianyang Central Hospital, School of Medicine,University of Electronic Science and Technology of China, No.12 Jingzhong Street, Mianyang, 621000, China. 384895848@qq.com.

Funding

China's National Key Clinical Specialty Construction Project in Gastroenterology XHZDZK013Incubation Project of Mianyang Central Hospital 2023FH004Philosophy and Social Sciences Health Humanities Research Center JKRWY24-14
6 · The paper itself

Abstract

backgroundThe anti-inflammatory diet exerts its effects by suppressing inflammatory mediators and modulating gut microbiota to reduce inflammation. However, its safety and efficacy in early nutritional management for patients with mild pancreatitis remain to be evaluated.

objectiveThis study aims to evaluate both the efficacy and safety of an early introduction of an anti-inflammatory diet in patients with mild acute pancreatitis.

methodsThis single-center randomized controlled trial enrolled 72 patients with mild acute pancreatitis (revised Atlanta criteria), randomly assigning 36 patients to each group. The intervention group received an early oral anti-inflammatory diet protocol featuring: ① oral intake initiation within 48 h; ② the daily food intake followed a diet with a Dietary Inflammatory Index (DII) score of less than 0, as formulated by the research group. The control group received conventional management: physician-directed oral intake initiation and a stepwise advancement from "clear liquid to full liquid to low-fat soft diet." Primary outcomes included inflammatory biomarkers, nutritional indicators, and gut microbiota (16S rRNA sequencing). Secondary outcomes were average hospital stay and costs. DISCUSSION: The positive findings of this study may offer novel clinical practice guidelines for early nutritional support in patients with mild acute pancreatitis. However, as a single-center study, further validation through multi-center studies with larger sample sizes is still required.

trial registrationChinese Clinical Trial Registry ChiCTR2400094056. https://www.chictr.org.cn/index.html .

Indexed as

PancreatitisAcute DiseaseAdministration, OralAdultChinaFemaleGastrointestinal MicrobiomeHumansInflammation MediatorsLength of StayMaleMiddle AgedNutritional StatusRandomized Controlled Trials as TopicSeverity of Illness IndexTime FactorsInflammation MediatorsAnti-inflammatory dietBody compositionDietary inflammatory indexGut microbiotaInflammationMild acute pancreatitis

Identifiers

PMID41668182
PMCPMC12990434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.