ReviewJournal of cannabis research2026
Comprehensive review on cannabis seed phenolic compounds from extraction to functional applications.
Review in Journal of cannabis research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of solvent polarity on phenolic antioxidant extraction fromRSC advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCannabis sativa L. seeds have long been regarded as a by-product of cannabis cultivation. Beyond their nutritional value, cannabis seeds are increasingly recognized as a source of specialized phenolic compounds with potential biological relevance. However, research on seed phenolics remains fragmented, often receiving only marginal attention, and a dedicated synthesis focused specifically on these compounds is still lacking. MAIN BODY: This review provides a focused and up-to-date synthesis of phenolic compounds reported in cannabis seeds, critically examining their chemical diversity, extraction and analytical strategies, and key factors influencing phenolic recovery and composition. Cannabis seeds exhibit a diverse phenolic profile dominated by hydroxycinnamic acid amides (mainly N-trans-caffeoyltyramine) and lignanamides (particularly Cannabisins A and B). Their extraction remains largely reliant on conventional solvent-based approaches, with limited adoption of innovative and green technologies, except for ultrasound assisted extraction. Advances in high-resolution analytical tools for phenolic separation and identification enabled comprehensive profiling and a deeper understanding of phenolic diversity. The extractability and final content of phenolic compounds result from a complex interplay between extraction-related parameters, biological variability, and seed processing conditions. Biological activities associated with cannabis seed phenolics include antioxidant, anticancer, neuroprotective, anti-inflammatory, dermo-protective, antibacterial, and metabolic regulatory effects. These activities are discussed with reference to reported mechanisms, such as free radical scavenging, modulation of inflammatory mediators, and inhibition of cancer cell proliferation.
conclusionCurrent evidence highlights cannabis seeds as a promising yet underexploited source of phenolic compounds with potential applications in nutraceutical, pharmaceutical, and dermato-cosmetic fields. Nevertheless, important challenges remain, such as methodological heterogeneity, limited in-vivo and clinical validation, and insufficient data on bioavailability and formulation. Addressing these limitations and gaps through standardized protocols, mechanistic studies, and translational research will be essential to support the effective valorization of cannabis seed phenolics in industrial and health-related applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.