Evidence map›Paper›PMID 41668084›Full record

ArticleBMC pulmonary medicine2026

Diagnostic challenges in primary pulmonary follicular dendritic cell sarcoma: 2 case reports.

Dongmei Ye, Xinyan Huang, Luoyan Wu, Minshi Ye, Zhaokang Zhou, Liping Xu, Yong Liu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Dongmei YeDepartment of Pathology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Xinyan HuangDepartment of Clinical Medicine, Gannan Medical University, Ganzhou, China.
Luoyan WuDepartment of Pathology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Minshi YeDepartment of Pathology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhaokang ZhouDepartment of Pathology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Liping XuDepartment of Pathology, The First Hospital of Nanchang, The Third Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. xlpchs2011@163.com.
Yong LiuDepartment of Pathology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China. jxpathology@126.com.

Funding

Key project of Science and Technology Plan of Jiangxi Provincial Health Commission NO. 202310091Key project of Science and Technology Plan of Jiangxi Provincial Health Commission NO. 202410012Nanchang City medical and health guiding technology plan project NO. 2023YLWS001
6 · The paper itself

Abstract

objectiveTo explore the clinical and pathological characteristics and the diagnosis and differential diagnosis of primary pulmonary follicular dendritic cell sarcoma (FDCS).

methodsClinical and pathological data from 2 cases of primary pulmonary FDCS were collected, and sections were prepared for haematoxylin-eosin (H&E) staining, immunohistochemistry (IHC) staining, and in situ hybridization (ISH). The relevant literature was reviewed. In both cases, the lesions presented as pulmonary masses.

resultsThe tumour cells demonstrated diffuse sheets, delicate eosinophilic cytoplasmic staining, oval nuclei and small nucleoli, and occasionally showing multinucleated or giant cells in some areas. Another important histological feature was the abundant infiltration of small lymphocytes among the tumour cells. The tumourcells were positive for one or more follicular dendritic cell (FDC) markers, including CD21, CD23, CD35 and podoplanin (D2-40). ISH revealed negative EBER expression. Both patients underwent surgical resection, and no recurrence or metastasis was observed.

conclusionFDCS has a unique histological morphology and immunophenotype for FDCS. It is rare for FDCS to occur in the lungs. However, owing to the lack of experience among doctors and the limitations of small biopsy specimens, FDCS can easily be misdiagnosed as lung cancer. When tumour cells exhibit the above histological features, additional immunostaining for FDC markers should be performed. The Clinical Trial Number is ChiCTR2400090730 and Reg Date is October 12, 2024.

Indexed as

Dendritic Cell Sarcoma, FollicularLung NeoplasmsAgedBiomarkers, TumorDiagnosis, DifferentialHumansImmunohistochemistryIn Situ HybridizationMaleMembrane GlycoproteinsMiddle AgedPodoplaninReceptors, Complement 3dReceptors, IgEBiomarkers, TumorMembrane GlycoproteinsPodoplaninReceptors, Complement 3dReceptors, IgECase reportDiagnosisDifferential diagnosisFollicular dendritic cell sarcomaLung

Identifiers

PMID41668084
PMCPMC12997965

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.