Evidence map›Paper›PMID 41667860›Full record

ArticleMolecular systems biology2026

Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets.

Oscar Camacho, Michael A Koldobskiy, Pradeep Reddy, Atharv Oak, Yuxiang Sun, Kenna Sherman, Juan Carlos Izpisua Belmonte, Andrew P Feinberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oscar Camacho *Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3413-9217
Michael A Koldobskiy *Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mak@jhmi.edu.ORCID http://orcid.org/0000-0002-2980-6644
Pradeep ReddySalk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9173-3845
Atharv OakCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuxiang SunDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Kenna ShermanCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Juan Carlos Izpisua BelmonteSalk Institute for Biological Studies, La Jolla, CA, USA. jcbelmonte@altoslabs.com.ORCID http://orcid.org/0000-0003-0557-8875
Andrew P FeinbergCenter for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. afeinberg@jhu.edu.ORCID http://orcid.org/0000-0002-8364-1991

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rejuvenation of tissues in physiologically aging mice can be accomplished by long-term partial reprogramming via expression of reprogramming factors (Oct4, Sox2, Klf4, and c-Myc). To investigate the epigenetic determinants of partial reprogramming-mediated rejuvenation, we used whole-genome bisulfite sequencing to carry out unbiased comprehensive profiling of DNA methylation changes in skin from mice subjected to partial reprogramming, as well as young and untreated old controls. We found a striking convergence of age- and rejuvenation-related epigenetic alterations on targets of the Polycomb repressive complex 2 (PRC2), with increased DNA methylation level and entropy over these regions. Native ChIP demonstrated extensive loss of H3K27me3 in aged epidermis compared to young, partially overlapping regions with age- and rejuvenation-related DNA methylation changes. In addition, large H3K9me2-marked "LOCK" heterochromatin domains defined the boundaries for hypomethylated highly entropic regions during aging. These results are also supported by a likewise prominent enrichment of PRC2 targets in gene expression data, suggesting that PRC2 activity can modulate aging and mediate tissue rejuvenation.

Indexed as

AgingEpigenesis, GeneticPolycomb Repressive Complex 2RejuvenationAnimalsCellular ReprogrammingDNA MethylationHeterochromatinHistonesKruppel-Like Factor 4MiceHeterochromatinHistonesKlf4 protein, mouseKruppel-Like Factor 4Polycomb Repressive Complex 2AgingDNA MethylationLOCKsPRC2Rejuvenation

Identifiers

PMID41667860
PMCPMC13144388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.