Evidence map›Paper›PMID 41667847›Full record

ArticleScientific reports2026

Multi-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress.

Wentao Dong, Yangyang Zheng, Yongfang Zhou, Tao Wang, Jiexin Yang, Huaying Li, Fanchao Li, Chuan Wang, Liang Liang, Hao Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wentao Dong *Emergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Yangyang Zheng *School of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Yongfang ZhouEmergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Tao WangEmergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Jiexin YangSchool of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Huaying LiSchool of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Fanchao LiSchool of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Chuan WangEmergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Liang LiangSchool of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Hao LiSchool of Clinical Medicine, Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Jian ZhangEmergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Wuxun PengEmergency Department, The Affliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China. pengwuxun0518@126.com.

Funding

Guizhou Provincial Natural Science Foundation Qiankehe Basic-[2024] youth 251Guizhou Provincial Natural Science Foundation Qiankehe Basic-[2024] youth 263Guizhou Provincial Natural Science Foundation Qiankehe basis-ZK [2023] general 345National Natural Science Foundation of China 82460426Start-up Fund for Doctoral Research of the Affiliated Hospital of Guizhou Medical University gyfybsky-2024-23Wu Jieping Medical Foundation 320.6750.2023-02-11
6 · The paper itself

Abstract

Human bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine. Identifying key factors that regulate hBMSCs osteogenic differentiation is crucial for enhancing bone regeneration strategies. This study aims to identify target genes underlying impaired osteogenic differentiation of hBMSCs under oxidative stress (OS) through integrated transcriptomic and proteomic approaches, and delineate the role of proenkephalin (PENK) in this process. OS model and impaired osteogenic differentiation model were established in hBMSCs using hydrogen peroxide (H

Indexed as

Cell DifferentiationMesenchymal Stem CellsOsteogenesisOxidative StressBone Marrow CellsCells, CulturedGene Expression ProfilingHumansHydrogen PeroxideMultiomicsProteomicsTranscriptomeHydrogen PeroxideBone marrow mesenchymal stromal cellsOsteogenic differentiationOxidative stressProteomicsTranscriptomics

Identifiers

PMID41667847
PMCPMC12963487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.