ArticleVirchows Archiv : an international journal of pathology2026
Gastric mesenchymal tumor with PTCH1::GLI2 fusion: a distinct subset of GLI1/GLI2-altered tumors?
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric mesenchymal tumors with GLI2 gene fusions are extremely rare, and only two cases, both with PTCH1::GLI2, have been reported. Here, we describe a third case involving a 47-year-old man. The tumor, measuring 4.5 cm in size, was distributed throughout the gastric wall transmurally with an infiltrative growth pattern. It had two spindle cell components, one arranged in tight bundles and the other in a loose reticular to vague fascicular pattern, and an epithelioid component lacking glandular formation. Immunohistochemically, CAM5.2 showed focal positivity in all components, SMA was positive in both spindle cell components, whereas desmin was positive only in the former. No recurrence was observed over 5 years. RNA sequencing identified a PTCH1::GLI2 fusion with GLI1, GLI2, and PTCH1 upregulation. The breakpoint was identical to those in the previously reported cases. Taken together, these findings suggest that PTCH1::GLI2 fusion may define a distinctive subtype of gastric mesenchymal tumors within the GLI1/GLI2-altered spectrum.
Indexed as
Identifiers
41667833What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.