Evidence map›Paper›PMID 41667797›Full record

ReviewCellular and molecular neurobiology2026

Decoding Alzheimer's Disease One Cell Class at a Time.

Martin Darvas, David G Cook, Annalisa Scimemi

Abstract readReview
In one paragraph

Review in Cellular and molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Martin DarvasDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, WA, 98104, USA.ORCID http://orcid.org/0000-0002-7942-2526
David G CookGeriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, 98108, USA.ORCID http://orcid.org/0009-0005-9184-013X
Annalisa ScimemiDepartment of Biology, SUNY Albany, Albany, NY, 12222, USA. ascimemi@albany.edu.ORCID http://orcid.org/0000-0003-4975-093X

Funding

Role of Astrocyte EAAT2/GLT1 Failure in Alzheimer's Disease PathogenesisR01AG075338 · NIA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Annalisa Scimemi · 2022 to 2026
$3.8M
Division of Integrative Organismal Systems IOS2011998NIA NIH HHS R01AG075338NINDS NIH HHS R56NS14042301
6 · The paper itself

Abstract

Multimodal imaging-based on single-cell genomics and spatial transcriptomics has shed new light on the taxonomy of genetically defined cell clusters in the mammalian brain. While transcriptomic approaches have revolutionized our ability to classify brain cells, their true value emerges when they are interpreted in conjunction with anatomical, physiological, and translational frameworks. Accordingly, significant progress has been made to elucidate relationships between gene expression, electrical and morphological properties of some of these clusters. This rapidly growing body of work shows not only that the cell cluster composition varies across brain regions but also evolves over time and changes during the progression of disease states like Alzheimer's disease. Given this complexity, integrating transcriptomic, structural, and functional data is now becoming essential for drawing meaningful comparisons across studies. In this review, we summarize these findings and discuss how this knowledge base is shifting towards more integrative approaches, quickly challenging current ideas regarding the genetic, molecular, and cellular underpinnings of Alzheimer's disease.

Indexed as

Alzheimer’s diseaseAstrocytesAtlasExcitatory neuronsInterneuronsMicrogliaOligodendrocytesPrincipal cellsRNA-seq

Identifiers

PMID41667797
PMCPMC12946330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.