ArticleBrain imaging and behavior2026
Cortical and subcortical gray matter alterations underlying sleep disturbances in patients with end-stage renal disease undergoing hemodialysis.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Although several studies have indicated a connection between cortical and subcortical structural abnormalities and sleep disturbances (SD) in patients with end-stage renal disease undergoing hemodialysis (HD), detailed characterization of these abnormalities remains unclear. In this study, twenty HD patients with SD (HD-SD), 20 HD patients without SD (HD-NSD) and 22 healthy controls were recruited and underwent clinical assessments, neuropsychological tests, and 3.0T MRI scans. Vertex-based analyses of cortical thickness, surface area and volume were conducted to examine cortical abnormalities between groups. Volumetric and vertex-wise shape analyses were performed to identify volumes and surfaces of subcortical structures. Correlations examined relationships between gray matter metrics, clinical data, and cognitive performance. ROC curve analyses were performed to identify metrics that differed between HD subgroups. Our results show that HD-SD patients exhibited cortical abnormalities in the frontal, temporal and parietal cortices, while HD-NSD patients showed abnormalities only in the frontal cortex. Both HD groups demonstrated subcortical morpho-volumetric changes in the hippocampus, basal ganglia, and thalamus, with right hippocampal contraction best differentiating HD-SD from HD-NSD. In HD patients, higher Pittsburgh Sleep Quality Index (PSQI) scores and more severe renal impairment were associated with cortical atrophy and subcortical shape alterations. Other neuropsychological markers in HD patients, including attention, working memory and negative emotions, shared cortical abnormalities mainly in the frontal and occipital cortex. Accordingly, our findings highlight the importance of distinguishing HD subgroups based on sleep quality, as this may provide valuable insights into the neurodegenerative mechanisms in this population.
Indexed as
Identifiers
41667761What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.