Observational studyNeurocritical care2026
Evaluation of Intracranial Pressure in Patients with Severe Brain Injury Using Contrast-Enhanced Ultrasound: A Pilot Study with Preliminary Findings.
Observational study in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundContrast-enhanced ultrasound (CEUS) has great potential for assessing increased intracranial pressure (ICP); however, the most appropriate parameters remain unknown. This study aimed to explore the application of quantitative analysis of CEUS diagnosing increased ICP in patients with severe brain injury after surgery, and to provide a novel idea for the non-invasive evaluation of ICP.
methodsThis observational study included 34 patients with craniocerebral injuries admitted to the intensive care unit from May 2022 to December 2023. Patients were divided into a normal cranial pressure group (< 20 mm Hg) and an intracranial hypertension group (≥ 20 mm Hg) on the basis of the invasive ICP monitoring values. All patients underwent CEUS examination within 24 h postoperatively. Time-intensity curves of the central retinal artery and short posterior ciliary artery were generated using CEUS quantitative analysis software. Quantitative parameters were obtained, and the difference was calculated. The diagnostic accuracy of each parameter was assessed by computing the area under the receiver operating characteristic curve (AUC).
resultsIn total, 15 patients (44%) had intracranial hypertension. The arrival time difference (ΔAT) and peak time difference (ΔTP) were significantly higher in the intracranial hypertension group than in the normal cranial pressure group (P < 0.001 and P = 0.010, respectively). The peak intensity difference (ΔPkI) was significantly lower in the intracranial hypertension group than in the normal cranial pressure group (P = 0.025). The diagnostic accuracy of ΔAT for identifying intracranial hypertension was excellent, with an AUC of 0.944 [95% confidence interval (CI) 0.874-1.014], which yielded an optimal cutoff value of 0.86 s with 93.3% sensitivity (95% CI 0.849-1.017) and 84.2% specificity (95% CI 0.719-0.964). The AUC of ΔAT was significantly higher than that of ΔTP and ΔPkI (AUC 0.761 and 0.721, respectively; both P < 0.05).
conclusionsThe CEUS quantitative analysis parameter, ΔAT, is a promising parameter for evaluating postoperative ICP elevation in patients with severe brain injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.