Evidence map›Paper›PMID 41667722›Full record

ArticleScientific reports2026

An intracortical brain-machine interface based on macaque ventral premotor activity.

Sofie De Schrijver, Jesus Garcia Ramirez, Santiago Iregui, Erwin Aertbeliën, Joris De Schutter, Tom Theys, Thomas Decramer, Peter Janssen

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sofie De Schrijver *Laboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven and the Leuven Brain Institute, Leuven, 3000, Belgium.
Jesus Garcia Ramirez *Research group Experimental Neurosurgery and Neuroanatomy, Leuven Brain Institute, KU Leuven, Leuven, 3000, Belgium.
Santiago IreguiDepartment of Mechanical Engineering, KU Leuven, and Flanders Make@KU Leuven, Leuven, 3001, Belgium.
Erwin AertbeliënDepartment of Mechanical Engineering, KU Leuven, and Flanders Make@KU Leuven, Leuven, 3001, Belgium.
Joris De SchutterDepartment of Mechanical Engineering, KU Leuven, and Flanders Make@KU Leuven, Leuven, 3001, Belgium.
Tom TheysResearch group Experimental Neurosurgery and Neuroanatomy, Leuven Brain Institute, KU Leuven, Leuven, 3000, Belgium.
Thomas DecramerResearch group Experimental Neurosurgery and Neuroanatomy, Leuven Brain Institute, KU Leuven, Leuven, 3000, Belgium.
Peter JanssenLaboratory for Neuro- and Psychophysiology, Department of Neurosciences, KU Leuven and the Leuven Brain Institute, Leuven, 3000, Belgium.

Funding

Fonds voor wetenschappelijk onderzoek Vlaanderen G.097422NOnderzoeksraad, KU Leuven C14/22/134
6 · The paper itself

Abstract

The majority of brain-machine interface (BMI) studies have focused on decoding intended movements based on neural activity of primary motor (M1) and dorsal premotor cortex (PMd). The ventral premotor cortex (PMv), and more specifically area F5c, has been implicated in object grasping and action observation, and may represent an alternative for motor BMI control due to its phasic modulation during action observation. Using chronically implanted Utah arrays in F5c, PMd, and M1 in two male macaques, we compared the efficacy of controlling a motor BMI based on neural activity of each area. PMv decoding reached similar or even higher success rates than M1 and PMd in a 2D cursor control task, especially when controlling for the number of motion selective channels that were used by the decoder. We found similar results during a 2D robot avatar control task in a simulated 3D environment. At both the multi-unit and the population level, neural responses in all areas were highly similar during the training phase (passive observation of cursor movements) and the online decoding phase, and only a small subset of neurons modulated its selectivity for the direction of motion. Thus, ventral premotor area F5c may represent an alternative for online motor BMI control.

Indexed as

Brain-Computer InterfacesMotor CortexAnimalsMacaca mulattaMaleMovementNeurons

Identifiers

PMID41667722
PMCPMC12972290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.