Evidence map›Paper›PMID 41667628›Full record

ReviewNpj imaging2026

The state of imaging glycolytic metabolism in cancer with magnetic resonance.

Mario C Chang, Matthew E Merritt, Kayvan R Keshari

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Npj imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mario C ChangDepartment of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL, USA.
Kayvan R KeshariDepartment of Radiology and Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rahimikk@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Leveraging fructose transport to create a privileged substrate to selectively fuel T cellsR01CA248364 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Kayvan R Keshari · 2021 to 2026
$4.3M
Development of large-field-of-view hyperpolarized MRIR01CA237466 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CUNNINGHAM, CHARLES H., HRICAK, HEDVIG · 2020 to 2024
$3.4M
Visualizing oxidative stress using hyperpolarized magnetic resonanceR01CA252037 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KESHARI, KAYVAN R · 2020 to 2024
$3.3M
Interrogation of the oxidative-stress-induced leukemia program in vivo usingmetabolic imagingR01CA283578 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Kayvan R Keshari, Michael Kharas · 2023 to 2026
$3.0M
Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapyR01CA249294 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KESHARI, KAYVAN R, MERGHOUB, TAHA · 2021 to 2025
$2.6M
Molecular Imaging in Cancer Biology Training ProgramT32CA254875 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Jason S. Lewis, Michael H. Overholtzer · 2021 to 2026
$2.1M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA237466NCI NIH HHS R01 CA248364NCI NIH HHS R01 CA249294NCI NIH HHS R01 CA252037NCI NIH HHS R01 CA283578NCI NIH HHS T32 CA254875NIH HHS R01CA237466; R01CA252037 ; R01CA248364 ; R01CA249294; R01CA283578; P30CA008748NIH HHS T32CA254875
6 · The paper itself

Abstract

Imaging is essential for probing cancer biology and tumor surveillance in humans. Combining isotopically labeled substrates with advanced imaging approaches yields a new platform, metabolic imaging. Although cancer metabolism research began ~100 years ago, breakthroughs in magnetic resonance imaging (MRI) like hyperpolarization, deuterium metabolic imaging, and novel probes have revolutionized our ability to appreciate deregulated glycolysis in cancer. Here, we discuss the state and future of glycolytic imaging with MRI.

Identifiers

PMID41667628
PMCPMC12891726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.