Evidence map›Paper›PMID 41667619›Full record

ArticleNature immunology2026

IL-4-STAT6 signaling delays protective CD8

Nicholas J Maurice, Talia S Dalzell, Trevor N Tankersley, Ka Hyun Rhee, Katharine E Block, Nicholas N Jarjour, Taylor A DePauw, Sarah M Wall, Sara E Hamilton, Stephen C Jameson

Abstract read
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicholas J MauriceCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. maurice@umn.edu.ORCID http://orcid.org/0000-0002-2667-472X
Talia S DalzellCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Trevor N TankersleyCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-5807-3179
Ka Hyun RheeCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Katharine E BlockCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9488-3577
Nicholas N JarjourCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-9400-4448
Taylor A DePauwCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Sarah M WallCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Sara E HamiltonCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-3768-7622
Stephen C JamesonCenter for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA. james024@umn.edu.ORCID http://orcid.org/0000-0001-9137-1146

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
T Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Understanding the functional agility of effector memory CD8 T cellsR01AI155468 · NIAID · UNIVERSITY OF MINNESOTA · PI HAMILTON HART, SARA ELIZABETH · 2021 to 2025
$2.8M
Profiling and leveraging bystander T cells within the tumor microenvironmentK00CA245735 · NCI · UNIVERSITY OF MINNESOTA · PI MAURICE, NICHOLAS JOSEPH · 2022 to 2025
$372k
Paving the way for bystander T cell immunotherapiesK99CA296729 · NCI · UNIVERSITY OF MINNESOTA · PI NICHOLAS JOSEPH MAURICE · 2025 to 2026
$228k
Cytokine regulation of recirculating and tissue-resident memory CD8+ T cells in homeostasis and inflammationK22AI177360 · NIAID · VERSITI BLOOD HEALTH, INC. · PI Nicholas N Jarjour · 2025 to 2026
$203k
Role of S1PRs and KLF transcription factors in CD8T cell traffickingF31AI188630 · NIAID · UNIVERSITY OF MINNESOTA · PI Taylor A DePauw · 2025 to 2026
$73k
Investigating mechanisms of bystander CD8 T cell mediated immunopathologyF30AI183705 · NIAID · UNIVERSITY OF MINNESOTA · PI WALL, SARAH M · 2025 to 2025
$43k
NCI NIH HHS K00 CA245735NCI NIH HHS K99 CA296729NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS F30 AI183705NIAID NIH HHS F31 AI188630NIAID NIH HHS K22 AI177360NIAID NIH HHS R01 AI038903NIAID NIH HHS R01 AI155468NIDA NIH HHS 75N95020D00005NIH HHS 75N93023D00005NIH HHS 75N99020D00005U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01 AI38903
6 · The paper itself

Abstract

Memory CD8

Indexed as

Bystander EffectCD8-Positive T-LymphocytesInterleukin-18Interleukin-4Lymphocyte ActivationSTAT6 Transcription FactorAnimalsImmunologic MemoryInterferon-gammaListeriosisMiceMice, Inbred C57BLMice, KnockoutReceptors, Interleukin-18Signal TransductionIl4 protein, mouseInterferon-gammaInterleukin-18Interleukin-4Receptors, Interleukin-18Stat6 protein, mouseSTAT6 Transcription Factor

Identifiers

PMID41667619
PMCPMC13360901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.