Evidence map›Paper›PMID 41667565›Full record

ArticleScientific reports2026

Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness.

Tayir Elami, Huadong Zhu, Reut Bruck-Haimson, Vijigisha Srivastava, Adam Zaretsky, Irit Cohen, Einav Gross, Ehud Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tayir ElamiDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Huadong ZhuDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Reut Bruck-HaimsonDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Vijigisha SrivastavaDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Adam ZaretskyDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Irit CohenDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Einav GrossDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel.
Ehud CohenDepartment of Biochemistry and Molecular Biology, the Institute for Medical Research Israel - Canada, Faculty of Medicine, The Hebrew University of Jerusalem, 9112001, Jerusalem, Israel. ehudc@ekmd.huji.ac.il.

Funding

Israel Science Foundation 534-21Israel Science Foundation 942/25Ministry of Science and Technology, Israel 100655
6 · The paper itself

Abstract

Post operative delirium (POD) is an acute complication, characterized by fluctuating attention and confusion, which may develop and persist into cognitive decline. POD is most commonly observed in elderly patients, particularly those with preexisting cognitive impairments. Isoflurane, a widely used volatile anesthetic, is associated with POD. However. how exposure to isoflurane affects the integrity of the proteome is largely obscure. Utilizing the nematode C. elegans, we found that isoflurane leads to a long-lasting decline in protein homeostasis (proteostasis) of adult animals that express neurodegeneration-causing, abnormally long poly-glutamine stretches. Isoflurane-induced proteostasis impairments are dependent on the aging-regulating transcription factors DAF-16/FOXO and SKN-1/NRF, and can be alleviated by the knockdown of certain components of the mitophagy mechanism. Accordingly, induction of mitochondrial biogenesis protects worms that are challenged by protein aggregation from isoflurane-induced proteotoxicity. Our observations provide novel insights into the mechanism that links isoflurane, proteotoxicity and POD, and highlight the potential of mitophagy modulators as alleviators of POD.

Indexed as

Anesthetics, InhalationCaenorhabditis elegansIsofluraneMitochondriaAgingAnimalsCaenorhabditis elegans ProteinsDNA-Binding ProteinsForkhead Transcription FactorsMitophagyProteostasisProteotoxic StressTranscription FactorsAnesthetics, InhalationCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDNA-Binding ProteinsForkhead Transcription FactorsIsofluraneskn-1 protein, C elegansTranscription FactorsAgingC. elegansIsofluraneMitochondriaProteostasisVolatile anesthetics

Identifiers

PMID41667565
PMCPMC12960726

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.