ArticleNature communications2026
Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Riley oxidation is a powerful method for introducing oxygen functionality but typically relies on toxic reagents and generally lacks enantiocontrol. This limitation has historically restricted the utility of this transformation for the direct asymmetric construction of complex scaffolds. Here, we show that fusion library screening and directed evolution enable the highly enantio- and diastereoselective Riley-type oxidation of a cis-diquinane substrate catalyzed by engineered P450
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