ArticleScientific data2026
Matched whole-genome sequencing of blood (10×) and five single sperm cells (1×) per individual in 53 men.
Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Asthenozoospermia, characterized by reduced sperm motility, is a major contributor to male infertility and motivates improved resources for studying spermatogenesis at the genomic level. Here, we present a paired whole-genome sequencing (WGS) dataset from 53 Han Chinese men, comprising matched blood WGS per participant (target ~10×) and 3-5 low-coverage single-sperm WGS libraries per participant (target ~1×). The dataset includes 263 single-sperm libraries (79 from 16 asthenozoospermic participants and 184 from 37 normozoospermic participants) and is accompanied by rich participant-level metadata, including baseline characteristics, endocrine measurements, and semen parameters such as sperm motility and vitality. Raw reads underwent standardized quality-control filtering, and key sequencing metrics (Q20 and GC content) met commonly used thresholds; the achieved mean depth was approximately 10× for blood and ~1.7× for single sperm. By integrating sperm motility/vitality phenotypes with individual-matched genomic information, this resource provides a foundation for male reproductive genomics and for developing and benchmarking algorithms for gamete-genome dissection, and may support future translational research on male infertility evaluation.
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