Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Yubo ZhangDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0009-0001-9372-4694
Vasiliki MatzarakiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-5852-6801
Nadira VadaqDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Marc J T BlaauwDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Wilhelm VosDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Albert GroenendijkDepartment of Internal Medicine and Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-2072-2532
Louise van EekerenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Janneke StalenhoefDepartment of Internal Medicine and Infectious Diseases, OLVG, Amsterdam, The Netherlands.ORCID 0000-0003-1486-3045
Marvin Ah BerrevoetsDepartment of Internal Medicine and Infectious Diseases, Elisabeth-Tweesteden Ziekenhuis, Tilburg, The Netherlands.
Casper RokxDepartment of Internal Medicine and Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-1904-6450
Mareva DelporteHIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.ORCID 0000-0002-4423-3012
Twan OttenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-2880-9111
Leo A B JoostenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0001-6166-9830
Cheng-Jian XuCentre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany.ORCID 0000-0003-1586-4672
Yang LiDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-4022-7341
Linos VandekerckhoveHIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.ORCID 0000-0002-8600-1631
Andre van der VenDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. andre.vanderven@radboudumc.nl.ORCID 0000-0003-1833-3391
Mihai G NeteaDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands. mihai.netea@radboudumc.nl.ORCID 0000-0003-2421-6052
Funding
ERC Advanced Grant
6 · The paper itself
Abstract
People with HIV (PWH) on combination antiretroviral therapy have an elevated risk for aging-related non-AIDS comorbidities. We assess whether HIV infection accelerates biological aging in two independent cohorts of PWH using six organ-specific and three organism-wide aging clocks derived from plasma proteomics of healthy individuals. Proteomic age acceleration significantly correlates with DNA methylation age and is linked to comorbidities and mortality. HIV infection accelerates systemic biological aging, with Mendelian randomization demonstrating causality between organ aging and inflammatory or metabolic complications. Accelerated aging in PWH is further related to the total HIV reservoir, and specific antiretroviral drugs reduce age acceleration. These data reveal important causal effects between chronic HIV infection, antiretroviral medication, biological aging and age-associated diseases, highlighting targets for improving health span in PWH.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.