Evidence map›Paper›PMID 41667488›Full record

ArticleNPJ Parkinson's disease2026

Genetic co-regulation of neopterin and Parkinson's disease.

Valeria Orrù, Michele Marongiu, Maristella Steri, Mara Marongiu, Carlo Sidore, Valentina Serra, Mauro Pala, Stefania Olla, Noemi Toggia, Matteo Floris and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Valeria Orrù *Institute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy. valeria.orru@cnr.it.
Michele Marongiu *Institute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Maristella Steri *Institute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Mara MarongiuInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Carlo SidoreInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Valentina SerraInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Mauro PalaInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Stefania OllaInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Noemi ToggiaInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Matteo FlorisInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Monia LobinaInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Maria Grazia PirasInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Antonella MulasInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Andrea MaschioInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Mariano DeiInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Marina ParoliniInstitute of Clinical Physiology, National Research Council, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milan, Italy.
Cinzia DellanoceInstitute of Clinical Physiology, National Research Council, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milan, Italy.
Alessandro DelitalaDepartment of Medicine, Surgery and Pharmacy, University of Sassari, 07100, Sassari, Italy.
23andMe Research Team
David SchlessingerNational Institute on Aging Intramural Research Program - NIH - 21224-6825, Baltimore, USA.
Jonica CampoloInstitute of Clinical Physiology, National Research Council, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milan, Italy.
Marcella DevotoInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Magdalena ZoledziewskaInstitute for Genetic and Biomedical Research, National Research Council, 09042, Monserrato, Italy.
Francesco CuccaInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.
Edoardo FiorilloInstitute for Genetic and Biomedical Research, National Research Council, 08045, Lanusei, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neopterin is a pro-inflammatory molecule upregulated in several diseases; however, its role in pathophysiology is unclear and its genetic regulation is unexplored. We observed that neopterin levels increase during senescence (P-value = 1.88×10

Identifiers

PMID41667488
PMCPMC13002981

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.