Evidence map›Paper›PMID 41667487›Full record

ArticleNature communications2026

Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior.

Haipeng Wang, Yujie Xiao, Wanyi Tang, Ke Lai, Qiang Ma, Xiaohui Zhao, Bo Li, Haibo Shi, Hao He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haipeng Wang *The Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China.
Yujie Xiao *College of Elementary Education, Capital Normal University, Beijing, China.
Wanyi TangThe Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China.ORCID 0000-0001-8347-6116
Ke LaiDepartment of Otorhinolaryngology Head & Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Qiang MaDepartment of Otorhinolaryngology Head & Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Xiaohui ZhaoThe Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China.
Bo LiDepartment of Neurology, Jinshan Hospital, State Key Laboratory of Medical Neurobiology, Ministry of Education (MOE), Frontiers Center for Brain Science, Institute for Translational Brain Research, Fudan University, Shanghai, China.
Haibo ShiDepartment of Otorhinolaryngology Head & Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.ORCID 0000-0002-2920-0183
Hao HeThe Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China. haohe@sjtu.edu.cn.ORCID 0000-0003-0832-8310

Funding

National Natural Science Foundation of China (National Science Foundation of China) 62022056, 61975118, and 92054105National Natural Science Foundation of China (National Science Foundation of China) T2222006
6 · The paper itself

Abstract

Precise control of the firing of an individual neuron in vivo is a key technology to neuroscience. The laser-induced ion channel opening makes it possible to depolarize neurons and trigger the firing. In this study, we present a noninvasive, opsin-free photostimulation method for activating an individual neuron within the primary visual cortex (V1). This activation is achieved through the transient local scanning of a tightly focused femtosecond laser on the soma of the target neuron that opens the store-operated calcium channels by multiphoton excitation, induces Ca

Indexed as

Action PotentialsNeuronsPrimary Visual CortexAnimalsBehavior, AnimalCalciumCalcium ChannelsFemaleLasersMaleMiceMice, Inbred C57BLPhotic StimulationPhotonsVisual CortexCalciumCalcium Channels

Identifiers

PMID41667487
PMCPMC13002923

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.