ArticleNature communications2026
Hypersensitive detection of single millimeter vascular emboli from adhesive in vivo.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Surgical adhesives are widely used in clinical practice but pose a significant risk of severe vascular embolism complications. Nevertheless, there are currently no non-invasive direct methods for precise detection of detached emboli. Herein, we show a CT-visualized method for hypersensitive detection of single millimeter vascular emboli from adhesive in vivo by simply doping BiOCl into surgical adhesives. As proof of concept, BiOCl-BioGlue with excellent CT imaging capability is fabricated and applied to repair ruptured vessels and liver in male rats. The location, morphology, and degradation process of BiOCl-BioGlue can be dynamically monitored by CT imaging for 42 days, and pulmonary emboli caused by BiOCl-BioGlue, with sizes as small as 1.2 mm, are successfully detected. Additionally, the high K-edge of Bi enables precise detection of pulmonary emboli in spectral CT imaging, unaffected by confounding calcifications. The proposed non-invasive detection strategy for adhesive emboli significantly enhances the biosafety of surgical adhesives.
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