ArticleNature communications2026
Cellular and transcriptional trajectories of neural fate specification in sea anemone uncover two modes of adult neurogenesis.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Extreme conservation of cnidarian stinging cell identity despite 600 million years of evolution.bioRxiv : the preprint server for biology · 2026Article
- Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
While neurogenesis is largely restricted to early life stages in animals, some taxa (including cnidarians, planarians and acoels) display lifelong neurogenic abilities. The cellular lineages and transcriptional programs underlying this process remain poorly understood in cnidarians. Combining reporter tracing and single-cell transcriptomics, we identify adult neurogenic trajectories in the sea anemone Nematostella vectensis. We uncover two distinct mechanisms: direct differentiation of peptidergic neurons from a multipotent progenitor pool, with identities specified proportionally to existing populations, and a stepwise maturation of cnidocytes (specialized cnidarian neural cells), marked by a transcriptionally distinct intermediate stage. Neural fate commitment is characterized by transient SoxC expression, with a homeodomain code associated with neural identities. These modular strategies support continuous neurogenesis and suggest that neural fate specification in cnidarians may use ancestral principles shared with bilaterians. Our study provides a foundational framework for understanding the mechanisms underlying the adult specification of neural cells and their evolutionary diversification across animal lineages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.