Evidence map›Paper›PMID 41667453›Full record

ArticleNPJ Regenerative medicine2026

Telomere shortening in laminopathic dilated cardiomyopathy.

Alex C Y Chang, Gaspard Pardon, Andrew C H Chang, Chenguang Wang, Vittavat Termglinchan, Anna Kirillova, Luka Nicin, Foster Birnbaum, Annie Laquerrière, Gisele Bonne and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alex C Y ChangDepartment of Cardiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. alexchang@shsmu.edu.cn.
Gaspard PardonBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Andrew C H ChangBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Chenguang WangDepartment of Cardiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Vittavat TermglinchanStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Anna KirillovaBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Luka NicinBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Foster BirnbaumBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Annie LaquerrièreUniv Rouen Normandie, INSERM U1245, Team Epigenetics and Pathophysiology of Neurodevelopmental Disorders and Department of Pathology, Rouen University Hospital, Rouen, France.
Gisele BonneCentre de Recherche en Myologie, Institut de Myologie, Sorbonne Universités, Paris, France.
Joseph WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Helen M BlauBaxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. hblau@stanford.edu.

Funding

ACTN4 Binding to Functional SNP rs9277336 Controls the Genome Architecture and Endothelial Pathophenotypes in Pulmonary ArterialF30HL170649 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anna Kirillova · 2023 to 2026
$198k
American Heart Association 13POST14480004American Heart Association 17CSA33590101American Heart Association 17MERIT33610009American Heart Association, United States 18POST34080160National Natural Science Foundation of China 82070248NHLBI NIH HHS F30 HL170649NIH HHS R01 AG044815Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning 0900000024Shanghai Pujiang Program 19PJ1407000Swiss National Science Foundation (SNSF) Early Postdoc Mobility Fellowship #P2SKP2_164954
6 · The paper itself

Abstract

Laminopathies are a group of rare disease due to mutations in the LMNA gene, which is crucial for nuclear integrity and cellular rigidity. Depending on the mutation, the disease manifests in striated muscles, adipose tissues, nerves, and the heart. Although many laminopathic patients exhibit accelerated aging syndromes, the connection as to why loss of LMNA drives aging remains unknown. Herein, we present evidence that cardiomyocytes from laminopathic heart sections exhibit shortened telomeres. Patient derived hiPSC-CMs we observed LMNA mutation results in myocardial enlargement and altered contractility in cardiomyocytes. Further, laminopathic murine cardiomyocytes recapitulates telomere attrition phenotype.

Identifiers

PMID41667453
PMCPMC13044268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.