Evidence map›Paper›PMID 41667447›Full record

ArticleNature communications2026

Molecular determinant of low-voltage dependence of human Na

Fang Zhao, Chuchu Xi, Jie Li, Kerui Ren, Qinglian Tang, Huaduan Liang, Shilong Yang, Michael X Zhu, Zhengyu Cao

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fang ZhaoState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Chuchu XiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Jie LiState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Kerui RenState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Qinglian TangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Huaduan LiangState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China.
Shilong YangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, 150040, China.ORCID 0000-0002-2618-1837
Michael X ZhuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. michael.x.zhu@uth.tmc.edu.ORCID 0000-0002-5676-841X
Zhengyu CaoState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, 211198, China. zycao1999@hotmail.com.ORCID 0000-0002-2692-2949

Funding

Lingang LaboratoryNational Natural Science Foundation of China (National Science Foundation of China) 81972960, 82373929National Natural Science Foundation of China (National Science Foundation of China) 82204653, 82100585
6 · The paper itself

Abstract

Na

Indexed as

NAV1.7 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channel BlockersAction PotentialsAnimalsGanglia, SpinalHEK293 CellsHumansInduced Pluripotent Stem CellsMyocytes, CardiacNeuronsRatsNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanVoltage-Gated Sodium Channel Blockers

Identifiers

PMID41667447
PMCPMC13000156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.