ArticleTranslational psychiatry2026
DNA methylation signatures associated with early-onset schizophrenia in Chinese patients.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Epigenetic legacy of early-life undernutrition: methodological lessons from Dutch and Chinese famine studies.Frontiers in genetics · 2026Review
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9 authors.
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Abstract
Schizophrenia is a heterogeneous psychiatric disorder with diverse clinical manifestations and complex biological mechanisms, in which age-at-onset (AAO) critically influences disease trajectory. Patients with early-onset schizophrenia (EOS; AAO < 18 years) present with more pronounced neurodevelopmental deficits and poorer long-term outcomes compared to adult-onset (AOS) cases. Previous genetic research on AAO and EOS has primarily focused on candidate genes and genome-wide association studies (GWAS). DNA methylation, an epigenetic mechanism influenced by the interplay between environmental and genetic factors, remains understudied, especially in the Chinese population. Peripheral blood DNA from 120 schizophrenia patients (49 EOS, 71 AOS) was analyzed using the Infinium MethylationEPIC v2.0 array. Differential methylated analyses were conducted for both EOS-AOS dichotomous comparison and continuous AAO, with stringent adjustment for age, sex, smoking, and estimated cell proportions. At a suggestive significance threshold (p < 5 × 10
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