ArticleAnesthesia and pain medicine2026
A comparative evaluation of efficacy of lignocaine and dexmedetomidine to attenuate hemodynamic and airway responses to endotracheal extubation in elective coronary artery bypass graft surgery: a prospective randomized double-blind clinical study.
Article in Anesthesia and pain medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
backgroundExtubation is more stressful than intubation because it leads to unpredictable hemodynamic and airway responses. Therefore, in this study, we compared the efficacy of dexmedetomidine and lignocaine in attenuating hemodynamic and airway responses during extubation in patients undergoing on-pump coronary artery bypass graft (CABG) surgeries.
methodsSeventy patients, aged 18-65 years, classified as American Society of Anesthesiologists physical status III and IV, were scheduled for elective on-pump CABG surgery under general anesthesia and prepared for extubation in the cardiac postoperative recovery room. They were randomly assigned to one of two groups: Dexmedetomidine Group (Group D, n = 35) received an intravenous (IV) bolus of dexmedetomidine at a dose of 0.5 µg/kg, while Lignocaine Group (Group L, n = 35) received an IV bolus of lignocaine at a dose of 1.5 mg/ kg, administered 5 min before extubation. Heart rate (HR) and mean arterial pressure (MAP) were measured at several intervals: prior to drug administration and at various times post-extubation. Statistical analysis was performed using the chi-squared test and a repeated-measures analysis of variance with Bonferroni correction.
resultsThe mean HR in Group D significantly decreased from E1 to E20 when compared with A0 (P < 0.05) and from E5 to E20 when compared with A1 (P < 0.05). By contrast, Group L showed significant variations in HR, at various time intervals.
conclusionsA single dose of dexmedetomidine (0.5 µg/kg) given 5 min prior to extubation significantly reduced post-extubation HR and improved extubation quality compared with lignocaine (1.5 mg/kg) in patients undergoing on-pump CABG surgeries.
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