ArticleBMJ open2026
Prevalence of asthma and gastro-oesophageal reflux disease, and their association with health-related quality-of-life: a cross-sectional study among a cohort of Sri Lankan adolescents.
Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study assessed the associations between asthma, gastro-oesophageal reflux disease (GORD) and health-related quality-of-life (HRQoL) among adolescents.
designA cross-sectional survey.
settingSix randomly selected schools across all five educational zones of the Anuradhapura district in Sri Lanka.
participantsA total of 1127 adolescents aged 13-14 years were included from six randomly selected schools representing all five educational zones in the Anuradhapura district, Sri Lanka.
main outcome measuresPrevalence of asthma and GORD, the associations between asthma, GORD and HRQoL among adolescents in Sri Lanka.
resultsThis study of 1127 adolescents (44.8% male, mean age 13.66±0.56 years) found that 16.1% (n=181) had current asthma and 17.9% (n=202) exhibited symptoms of GORD. A significant association was observed between current asthma and GORD (OR 2.30, 95% CI 1.59 to 3.31, p=0.0005). Comorbidity of asthma and GORD was observed in 4.8% of participants (n=54). The total HRQoL score was not associated with asthma, GORD or those having both asthma and GORD. However, the presence of GORD was associated with poor emotional functioning (unstandardized regression coefficient ± standard error = -4.7±1.7, p=0.008).
conclusionAsthma and GORD were significantly associated among early adolescents in Sri Lanka. While overall HRQoL did not differ by disease status, the presence of GORD was associated with poorer emotional functioning.
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