Evidence map›Paper›PMID 41667037›Full record

ArticleTumour virus research2026

30-hydroxygambogic acid activates overlapping and independent apoptotic pathways in HPV positive and HPV negative oral cancer cells.

Danelle Grubbs, Sonia Whang, Valeria Rodarte, Briza Martinez, Valeri Filippov, John Chen, Jaqueline Coats, Julia Unternaehrer, Isaac Kremsky, Brigitte Vazquez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tumour virus research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Danelle GrubbsDepartment of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Sonia WhangDepartment of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Valeria RodarteDepartment of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Briza MartinezDepartment of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA; University of Redlands, Redlands, CA, USA.
Valeri FilippovDivision of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
John ChenCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Jaqueline CoatsDivision of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Julia UnternaehrerDivision of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Isaac KremskyDepartment of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA; Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Brigitte VazquezDivision of Biochemistry, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
Penelope J Duerksen-HughesDepartment of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA. Electronic address: pdhughes@llu.edu.

Funding

Targeting CRLF2 and Ikaros Alterations to Reduce Health Disparities in Childhood LeukemiaR01CA209829 · NCI · LOMA LINDA UNIVERSITY · PI DOVAT, SINISA, DUERKSEN-HUGHES, PENELOPE J · 2016 to 2020
$2.0M
Inhibition of the TNF Apoptotic Pathway by HPV 16 E6R01CA095461 · NCI · LOMA LINDA UNIVERSITY · PI DUERKSEN-HUGHES, PENELOPE J · 2003 to 2007
$1.5M
iSPIN iCorp TrainingR43CA221479 · NCI · ISPIN, INC. · PI DUERKSEN-HUGHES, PENELOPE J · 2017 to 2018
$241k
HTS Screening for Inhibitors of HPV 16 E6/Caspase 8 BindingR21NS073059 · NINDS · LOMA LINDA UNIVERSITY · PI DUERKSEN-HUGHES, PENELOPE J · 2010 to 2013
$200k
NCI NIH HHS R01 CA095461NCI NIH HHS R01 CA209829NCI NIH HHS R43 CA221479NINDS NIH HHS R21 NS073059
6 · The paper itself

Abstract

The global incidence of Head and Neck (HN) cancer has dramatically increased over the past few decades, primarily due to an increasing incidence of HPV infection. HPV infection desensitizes cells to apoptosis through the E6-enabled accelerated degradation of several pro-apoptotic molecules, including p53 and procaspase 8. To block this activity, we used 30-hydroxygambogic acid, GA-OH, a small molecule that binds to HPV16 E6 and inhibits the interactions of E6 with its cellular partners. We found that treatment with GA-OH affects the viability of both HPV(+) and HPV(-) oral cancer cells. Further analysis of gene expression patterns of these cell lines showed that GA-OH induces cell death through both independent and overlapping apoptotic pathways by altering gene expression in both HPV(+) and HPV(-) cancer cells.

Indexed as

ApoptosisHuman papillomavirus 16Mouth NeoplasmsPapillomavirus InfectionsCaspase 8Cell Line, TumorCell SurvivalHumansOncogene Proteins, ViralRepressor ProteinsTumor Suppressor Protein p53Caspase 8E6 protein, Human papillomavirus type 16Oncogene Proteins, ViralRepressor ProteinsTumor Suppressor Protein p5330-Hydroxygambogic acidApoptosisE6HPV16Oral cancerTranscriptome

Identifiers

PMID41667037
PMCPMC12933592

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.