Evidence map›Paper›PMID 41666959›Full record

ArticleMolecules and cells2026

Structure of the melatonin-related orphan receptor, GPR50.

Jinwoo Shin, Dongyoung Baek, Jihan Kim, Junhyeon Park, Eunyoung Jeong, Yoojoong Kim, Young Jin Kim, Yunje Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinwoo ShinDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Dongyoung BaekDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Jihan KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Junhyeon ParkDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Eunyoung JeongDepartment of Molecular Sociology, Max Planck Institute for Biophysics, Frankfurt am Main, Germany; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Yoojoong KimDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Young Jin KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Yunje ChoDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea; Department of Medical Science and Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea. Electronic address: yunje@postech.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GPR50 is an orphan G-protein-coupled receptors that belongs to the member of melatonin-related receptor family. GPR50 plays roles in various physiological processes, including cancer progression, Notch signaling, and insulin, leptin, and glucocorticoid signaling. GPR50 forms a complex with melatonin-receptor type 1A or 1B, and regulates signaling activity of melatonin-receptor type 1A. Although endogenous agonists have not been characterized, GPR50 may have its own signaling activity, which is undefined at present. In this study, in an attempt to characterize the orphan activity of GPR50, we determined the 3.4 Å structure of ligand-free GPR50 using cryo-electron microscopy. We showed that GPR50 exhibits moderate constitutive activity through interaction with Gα

Indexed as

Receptors, G-Protein-CoupledAnimalsBinding SitesCryoelectron MicroscopyHEK293 CellsHumansLigandsMelatoninModels, MolecularNerve Tissue ProteinsReceptors, MelatoninSignal TransductionGPR50 protein, humanLigandsMelatoninNerve Tissue ProteinsReceptors, G-Protein-CoupledReceptors, MelatoninCryo-EM structureGPR50Ligand access channelMelatonin-related receptorOrphan G-protein–coupled receptors

Identifiers

PMID41666959
PMCPMC12954307

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.