Evidence map›Paper›PMID 41666436›Full record

ArticleJournal of applied toxicology : JAT2026

In Vitro Percutaneous Absorption of Dehydroacetic Acid and Benzoic Acid From Pig Skin Using the Franz Diffusion Cell System.

Han Nah Chung, Hyang Yeon Kim, Ji Woo Kim, Jung Dae Lee, Gi-Wook Hwang, Kyu-Bong Kim

Abstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Han Nah ChungCollege of Pharmacy, Dankook University, Cheonan, Republic of Korea.
Hyang Yeon KimCollege of Pharmacy, Dankook University, Cheonan, Republic of Korea.
Ji Woo KimCollege of Pharmacy, Dankook University, Cheonan, Republic of Korea.
Jung Dae LeeCollege of Pharmacy, Dankook University, Cheonan, Republic of Korea.
Gi-Wook HwangDivision of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Kyu-Bong KimCollege of Pharmacy, Dankook University, Cheonan, Republic of Korea.

Funding

Ministry of Food and Drug Safety 24202MFDS267Ministry of Food and Drug Safety 24202MFDS269
6 · The paper itself

Abstract

Dehydroacetic acid (DA) and benzoic acid (BA) are used as preservative agents in cosmetics in Korea at maximum concentrations of 0.6% and 0.5%, respectively. Prior to conducting the percutaneous absorption study, analytical methods were developed and validated for the quantification of DA and BA in various matrices including swab (SW), stratum corneum (SC), full-thickness skin (dermis + epidermis, SK), and receptor fluid (RF). These methods demonstrated excellent linearity (r

Indexed as

Benzoic AcidPreservatives, PharmaceuticalSkinSkin AbsorptionAnimalsPyronesReproducibility of ResultsSwineTandem Mass SpectrometryBenzoic Aciddehydroacetic acidPreservatives, PharmaceuticalPyronesbenzoic aciddehydroacetic acidFranz diffusion methodin vitro percutaneous absorptionLC–MS/MSpig skin

Identifiers

PMID41666436
PMCPMC13432746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.