Evidence map›Paper›PMID 41666093›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Point-of-Care Urine Tenofovir Drug-Level Feedback Counseling Improves Long-Term Pre-exposure Prophylaxis Adherence for US Men Who Have Sex With Men in Pilot RCT.

Matthew A Spinelli, Leah Davis Ewart, Emily J Ross, Megan J Heise, Renata Buccheri, Carlos Moreira, Shivani Mahuvakar, David V Glidden, K Rivet Amico, Emily Arnold and 7 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Matthew A SpinelliDepartment of Medicine, University of California, SanFrancisco, California, USA.
Leah Davis EwartDepartment of Health Promotion and Disease Prevention, Florida International University, Miami, Florida, USA.
Emily J RossDepartment of Health Promotion and Disease Prevention, Florida International University, Miami, Florida, USA.
Megan J HeiseDepartment of Medicine, University of California, SanFrancisco, California, USA.ORCID 0000-0001-6651-2381
Renata BuccheriDepartment of Medicine, University of California, SanFrancisco, California, USA.ORCID 0000-0002-3217-5898
Carlos MoreiraDepartment of Medicine, University of California, SanFrancisco, California, USA.
Shivani MahuvakarDepartment of Medicine, University of California, SanFrancisco, California, USA.ORCID 0009-0006-9406-4081
David V GliddenDepartment of Medicine, University of California, SanFrancisco, California, USA.ORCID 0000-0001-5888-1419
K Rivet AmicoDepartment of Health Behavior and Health Equity, University of Michigan, Ann Arbor, Michigan, USA.
Emily ArnoldDepartment of Medicine, University of California, SanFrancisco, California, USA.
Warren RodriguesAbbott Rapid Diagnostics, Pomona, California, USA.
Hideaki OkochiDepartment of Medicine, University of California, SanFrancisco, California, USA.
Jennifer ManuelDepartment of Medicine, University of California, SanFrancisco, California, USA.
Margaret HandleyDepartment of Medicine, University of California, SanFrancisco, California, USA.
Susan P BuchbinderDepartment of Medicine, University of California, SanFrancisco, California, USA.ORCID 0000-0003-2404-0712
Adam CarricoDepartment of Health Promotion and Disease Prevention, Florida International University, Miami, Florida, USA.
Monica GandhiDepartment of Medicine, University of California, SanFrancisco, California, USA.ORCID 0000-0002-7025-1994

Funding

PrEP Point-of-Care Brief-Intervention for Adherence among Young Men Who Have Sex with Men (PrEP2-BAY Study)K23MH122286 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINELLI, MATTHEW A. · 2020 to 2024
$1.0M
NIH HHS 2R01AI143340NIH HHS K23MH122286
6 · The paper itself

Abstract

A remote, motivational interviewing-informed intervention using self-administered point-of-care urine tenofovir testing improved long-term pre-exposure prophylaxis (PrEP) adherence among young US men-who-have-sex-with-men in a pilot randomized trial. Participants increased hair tenofovir levels by 1-2 tablets weekly, with high feasibility and acceptability, supporting further implementation.

Indexed as

Adherence InterventionsCounselingHIV InfectionsMedication AdherencePoint-of-Care SystemsPre-Exposure ProphylaxisTenofovirAdultAnti-HIV AgentsHairHomosexuality, MaleHumansMaleMotivational InterviewingPilot ProjectsUnited StatesAnti-HIV AgentsTenofoviradherence interventionmotivational interviewingpoint-of-carePrEPurine tenofovir

Identifiers

PMID41666093
PMCPMC13189661

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.