ArticleProceedings of the National Academy of Sciences of the United States of America2026
Methionine-specific nonreversible bioconjugation: Advancing precision protein modification.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We present a methionine-selective, nonreversible bioconjugation strategy that employs activated allylic bromides under mild, aqueous reaction conditions compatible with various peptides and proteins. Compared with conventional allylic bromides, our method improves conjugate stability and suppresses nonspecific reactivity under the examined reaction conditions. This method enables methionine-preferred labeling of peptides and proteins, and provides proof-of-concept applications in covalent inhibitor design and protein functionalization. As a complementary addition to existing methionine bioconjugation strategies, this chemistry expands the toolkit available for protein modification and chemical biology research.
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