Evidence map›Paper›PMID 41665937›Full record

ArticleThe Journal of clinical investigation2026

Sinus mast cell accumulation and persistence suggest a unique endotype in toxin exposure-associated chronic rhinosinusitis.

Xinyu Wang, Yung-An Huang, Anshika Sethi, Christopher Yue, Sydney Brack, Aiswarya Chattuparambil Binoy, Lauren Crowther, Carol Yan, Adam Deconde, Anton Kushnaryov and 8 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xinyu WangVA San Diego Healthcare System, La Jolla, California, USA.
Yung-An HuangVA San Diego Healthcare System, La Jolla, California, USA.
Anshika SethiVA San Diego Healthcare System, La Jolla, California, USA.
Christopher YueVA San Diego Healthcare System, La Jolla, California, USA.
Sydney BrackVA San Diego Healthcare System, La Jolla, California, USA.
Aiswarya Chattuparambil BinoyVA San Diego Healthcare System, La Jolla, California, USA.
Lauren CrowtherDivision of Allergy & Immunology and.
Carol YanVA San Diego Healthcare System, La Jolla, California, USA.
Adam DecondeDepartment of Otolaryngology-Head and Neck Surgery, UCSD, La Jolla, California, USA.
Anton KushnaryovVA San Diego Healthcare System, La Jolla, California, USA.
Andrew Vahabzadeh-HaghVA San Diego Healthcare System, La Jolla, California, USA.
Jacob HussemanVA San Diego Healthcare System, La Jolla, California, USA.
Maia LittleVA San Diego Healthcare System, La Jolla, California, USA.
Allyssa StrohmVA San Diego Healthcare System, La Jolla, California, USA.
Lily JihVA San Diego Healthcare System, La Jolla, California, USA.
Jonathan J LyonsVA San Diego Healthcare System, La Jolla, California, USA.
David H BroideDivision of Allergy & Immunology and.
Taylor A DohertyVA San Diego Healthcare System, La Jolla, California, USA.

Funding

Mentoring patient-oriented researchers in inflammatory airway diseaseK24AI171795 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR A DOHERTY · 2022 to 2026
$968k
BLRD VA I01 BX005073NIAID NIH HHS K24 AI171795
6 · The paper itself

Abstract

This study identifies a toxin-associated chronic rhinosinusitis endotype, defined by persistent mast cell accumulation, advancing understanding of how environmental exposures may drive chronic airway disease.

Indexed as

Mast CellsParanasal SinusesRhinosinusitisSinusitisAnimalsChronic DiseaseHumansAllergyImmunologyInflammationMast cells

Identifiers

PMID41665937
PMCPMC13078863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.