Evidence map›Paper›PMID 41665934›Full record

ArticleThe Journal of clinical investigation2026

Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases.

Bingyu Yan, Jinwoo Lee, Suhas Srinivasan, Pedro Ambriz, Quanming Shi, Diana R Dou, Srijana Davuluri, Swarna Nandyala, Adrianne Woods, Gwendolyn Leatherman and 8 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Bingyu YanDepartment of Dermatology and.
Jinwoo LeeDepartment of Dermatology and.
Suhas SrinivasanDepartment of Dermatology and.
Pedro AmbrizDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Quanming ShiDepartment of Dermatology and.
Diana R DouDepartment of Dermatology and.
Srijana DavuluriDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Swarna NandyalaDepartment of Dermatology and.
Adrianne WoodsDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gwendolyn LeathermanDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yanding ZhaoDepartment of Dermatology and.
Roman E ReggiardoDepartment of Dermatology and.
Manasi SawantDepartment of Bioengineering and.
Hawa Racine ThiamDepartment of Bioengineering and.
Ami A ShahDivision of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
David F FiorentinoDepartment of Dermatology and.
Lorinda S ChungDepartment of Dermatology and.
Howard Y ChangDepartment of Dermatology and.

Funding

Autoantibodies Define Scleroderma Subgroups with Distinct Relationships to CancerR01AR073208 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI LIVIA A CASCIOLA-ROSEN, Ami Aalok Shah · 2018 to 2026
$5.2M
Harnessing multivariate patient- and population-level disease trajectories to predict major clinical events in sclerodermaK24AR080217 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Ami Aalok Shah · 2022 to 2026
$847k
"Lnc"ing XIST Ribonucleoprotein Particles to Female Sex-Attributed Biases in AutoimmunityR00AR080218 · NIAMS · DUKE UNIVERSITY · PI Diana Remy Dou · 2025 to 2026
$486k
"Lnc"ing XIST Ribonucleoprotein Particles to Female Sex-Attributed Biases in AutoimmunityK99AR080218 · NIAMS · STANFORD UNIVERSITY · PI DOU, DIANA REMY · 2022 to 2023
$211k
NIAMS NIH HHS K24 AR080217NIAMS NIH HHS K99 AR080218NIAMS NIH HHS R00 AR080218NIAMS NIH HHS R01 AR073208
6 · The paper itself

Abstract

Novel autoantibodies target hotspots on the XIST ribonucleoprotein complex in female-biased autoimmune diseases.

Indexed as

AutoantibodiesAnimalsAutoimmune DiseasesFemaleHumansMiceRibonucleoproteinsRNA, Long NoncodingAutoantibodiesRibonucleoproteinsRNA, Long NoncodingXIST non-coding RNAAntigenAutoimmune diseasesAutoimmunityBiomarkersImmunologyInflammation

Identifiers

PMID41665934
PMCPMC13038191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.