SynthesisOdontology2026
Respiratory problems in early childhood and molar-incisor hypomineralization: systematic review and meta-analysis.
Synthesis in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo evaluate the association between early childhood respiratory problems and Molar-Incisor Hypomineralization (MIH).
methodsObservational studies assessing the relationship between early respiratory diseases and MIH were included. Two independent reviewers conducted comprehensive searches in MEDLINE-PubMed, Scopus, EMBASE, Web of Science, Google Scholar
resultsFrom 1228 identified articles, 27 met the inclusion criteria, and 12 were included in four meta-analyses. Most cross-sectional and cohort studies showed low risk of bias, while case-control studies showed moderate risk. Quantitative synthesis was feasible only for asthma and pneumonia. In adjusted analyses, asthma was not significantly associated with MIH (OR 1.93; 95% CI 0.60-6.20), with substantial heterogeneity across studies. Pneumonia showed a positive overall association with MIH (OR 3.33; 95% CI 1.05-10.51). However, the certainty of evidence for all associations was considered very low.
conclusionEarly childhood respiratory conditions may be associated with molar-incisor hypomineralization, but the available evidence is inconsistent and of very low certainty, precluding causal inference.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.