Evidence map›Paper›PMID 41665742›Full record

ReviewInflammopharmacology2026

Elderberry (Sambucus nigra L.): an ethnopharmacological, phytochemical and biological review for a prospective nutraceutical plant.

Asmaa M Khalil, Rania M Kamal, Riham A El-Shiekh, Ahmed H Elbanna, Sherif A Hamdy

Abstract readReview
In one paragraph

Review in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asmaa M KhalilFaculty of Pharmacy, Pharmacognosy Department, Cairo University, Cairo, 11562, Egypt.
Rania M KamalFaculty of Pharmacy, Pharmacognosy Department, Cairo University, Cairo, 11562, Egypt. rania.ahmed@pharma.cu.edu.eg.
Riham A El-ShiekhFaculty of Pharmacy, Pharmacognosy Department, Cairo University, Cairo, 11562, Egypt. riham.adel@pharma.cu.edu.eg.
Ahmed H ElbannaFaculty of Pharmacy, Pharmacognosy Department, Cairo University, Cairo, 11562, Egypt.
Sherif A HamdyFaculty of Pharmacy, Pharmacognosy Department, Cairo University, Cairo, 11562, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElderberry (Sambucus nigra L.) has been traditionally implemented in diverse preparations such as herbal teas, syrups or juices as remedies for respiratory, febrile and other health conditions. Phytochemical and chromatographic analyses of different organs mapped their metabolite profiles and allowed identification, and sometimes isolation, of their main bioactive compounds. AIM OF THE STUDY: Inspired by the rich and effective literature of S. nigra, this review article aims to summarize and highlight its reported biological (traditional and research-based) and chemical profiles.

methodsThe Keywords used in the search included biological activities, pharmacological reports, phytochemistry, isolated compounds, taxonomy, botanical data, single or combination; traditional, traditionally, ethnopharmacology, folk uses, toxicity, LD50, interactions, side effects, clinical studies, elderberry, elder, Sambucus nigra. Using different bibliographic databases, Google Scholar, PubMed, Web of Science, Springer Link, and Science Direct with no specific limits.

resultsIn this context, elderberry is deemed a rich source for a myriad of bioactive compounds, mainly phenolics, and was proven to exhibit a variety of health benefits, including antioxidant, anti-inflammatory, anticancer, anti-influenza, antimicrobial, antidiabetic, cardioprotective, and neuroprotective properties. This review also covers different analysis approaches applied for S. nigra characterization in addition to literature studies attempted to optimize its extract(s) preparation process in terms of different extraction solvents, temperatures or methodologies to enrich prepared extracts in beneficial and bioactive metabolites.

conclusionOverall, elderberry holds substantial potential as a rich dietary source of bioactive metabolites. Future research into its application in functional foods and nutraceuticals may provide innovative strategies for the prevention and management of various chronic diseases. CLINICAL TRIAL NUMBER IN THE MANUSCRIPT: Not applicable.

Indexed as

Dietary SupplementsPhytochemicalsPlant ExtractsSambucus nigraAnimalsEthnopharmacologyHumansPhytochemicalsPlant ExtractsBioactive metabolitesElderberryExtracts optimizationNutraceuticalsSambucus nigra LTraditional uses

Identifiers

PMID41665742
PMCPMC12995950

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.