Evidence map›Paper›PMID 41665722›Full record

ArticleCurrent microbiology2026

Recombinant AMPs (Epinecidin-1 and its Variants): A New Hope against Invasive Fungal Infections against Candida spp. and Aspergillus flavus.

Ansu Susan Peter, Indira Kandasamy, Sukumar Ranjith, Sivakumar Jeyarajan, Prahalathan Chidambaram, Anbarasu Kumarasamy

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Identification of the Biocontrol Effect ofJournal of fungi (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ansu Susan PeterMicrobial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Indira KandasamyMicrobial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Sukumar RanjithMicrobial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Sivakumar JeyarajanMicrobial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Prahalathan ChidambaramDepartment of Biochemistry, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Anbarasu KumarasamyMicrobial Biotechnology Laboratory, Department of Marine Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. anbumbt@bdu.ac.in.

Funding

ICMR IIRPSG-2024-01-01898, dt.11.02.2025RUSA 2.0 Biological Sciences 311/RUSA(2.0)/2018Tamil Nadu State Council for Higher Education 01706/P6/2021
6 · The paper itself

Abstract

To enhance stability and antimicrobial efficacy of antimicrobial peptide (AMP) epinecidin-1, we previously engineered three variants - GK-epi-1, Variant-1 and Variant-2-by substituting alanine and histidine residues with lysine. Our current study focuses on the antifungal capabilities of Epinecidin-1 and its variants against the clinical isolates of Candida spp. (Candida albicans, C. tropicalis, C. krusei & C. glabrata) and Aspergillus flavus. Computational docking studies are evidenced, the peptides had strong affinity against all fungal receptor examined which indicates their efficacy to interact with the Candida cell membrane receptors (Exo-B-(1,3)-Glucanase, Secreted aspartic proteinase (SAP) 1 & N-terminal domain adhesin: Als 9 - 2). Minimum Inhibitory Concentration (MIC), Minimum Fungicidal Concentration (MFC) and antibiofilm assays revealed its potent antifungal activity, particularly in disrupting biofilm formation. Effects of peptides on hyphal growth inhibition activity and Scanning Electron Microscopy (SEM) confirmed that the mechanism of action involves pore formation, hyphal disruption and induction of reactive oxygen species in Candida cell membrane. The antifungal spectrum was extended to A. flavus, a known ocular pathogen, where combination therapy using sub-inhibitory concentrations of Epinecidin-1 and its variant peptides with Amphotericin B and Miconazole showed enhanced synergistic effects, reducing required dosages for effective pathogen control.

Indexed as

Antifungal AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAspergillus flavusCandidaBiofilmsCandidiasisFish ProteinsHyphaeMicrobial Sensitivity TestsMolecular Docking SimulationRecombinant ProteinsAntifungal AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptidesepinecidin-1, Epinephelus coioidesFish ProteinsRecombinant ProteinsAntimicrobial peptidesEpinecidin-1Fungal pathogensScanning electron microscopeSynergismVariants

Identifiers

PMID41665722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.