Rural-urban disparities in breast cancer incidence among US women aged 20-49: trends by race/ethnicity, stage, poverty, and state from 2000-2019.

Katherine L Ho, Michael R Desjardins, Kassandra I Alcaraz, Avonne E Connor

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Article in Cancer causes & control : CCC, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Katherine L HoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St. , Baltimore, MD, 21205, USA.ORCID https://orcid.org/0000-0002-2836-9446

Michael R DesjardinsDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St. , Baltimore, MD, 21205, USA.ORCID https://orcid.org/0000-0002-2789-5460

Kassandra I AlcarazDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St. , Baltimore, MD, 21205, USA.

Avonne E ConnorDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St. , Baltimore, MD, 21205, USA. aconnor8@jhu.edu.ORCID https://orcid.org/0000-0002-7453-3892

Funding

INSTITUTIONAL RESEARCH CANCER EPIDEMIOLOGY FELLOWSHIPT32CA009314 · NCI · JOHNS HOPKINS UNIVERSITY · PI Corinne E. Joshu, Meghan Bridgid Moran · 1985 to 2026

$11.2M

NCI NIH HHS T32 CA009314NIH HHS T32CA009314

6 · The paper itself

Abstract

purposeTo explore patterns in rising breast cancer (BC) incidence trends by rurality among younger women aged < 50.

methodsWe analyzed incidence data from the North American Association of Central Cancer Registries to assess trends in early-onset BC (ages 20-49) from 2000-2019 in the United States, stratified by rurality (USDA rural-urban continuum codes), stage, race/ethnicity, poverty (< 5%, 5- < 10%, 10- < 20%, ≥ 20% below poverty), and state. We extracted age-adjusted incidence rates (aIR) (2000 US standard population) for each year and used the joinpoint regression program to detect significant trends over time, calculating annual percentage changes (APC) and average annual percentage changes (AAPC

resultsOf the 836,012 patients (87.7% urban, 12.3% rural), BC incidence was similar in urban (aIR = 69.3/100,000; AAPC + 0.52%) and rural counties (aIR = 61.6/100,000; AAPC + 0.43%) from 2000-2019. Localized stage BC increased (APC

conclusionsEarly-onset BC rose between 2000-2019 in both urban and rural areas, with differences by stage, race and ethnicity, poverty, and state. More research is needed to understand how rurality intersects with SES, healthcare access, screening, and incidence for women aged 20-49.

Indexed as

Breast NeoplasmsHealth Status DisparitiesRural PopulationUrban PopulationAdultEthnicityFemaleHumansIncidenceMiddle AgedNeoplasm StagingPovertyRacial GroupsRegistriesSocioeconomic Disparities in HealthUnited StatesBreast cancerEarly-onsetGeographic disparitiesTrends

Identifiers

PMID41665696

DOI10.1016/j.sste.2013.03.002

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