ReviewCellular and molecular life sciences : CMLS2026
Decoding vascular calcification: mechanistic insights and translational strategies.
Review in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pathological depositions in human disease: converging mechanisms in atherosclerosis, Alzheimer's disease, and related disorders.Molecular biomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular calcification (VC) is a complex, multifactorial process strongly associated with ageing, atherosclerosis, chronic kidney disease, and diabetes. Despite its clinical significance, effective treatment strategies remain elusive due to an incomplete understanding of the underlying mechanisms. In this review, we critically examine the cellular and molecular pathways that drive VC, including the transdifferentiation of vascular smooth muscle cells (VSMCs), the role of extracellular vesicles, and the influence of oxidative stress and inflammation. We also summarise key inducers and endogenous inhibitors of calcification, highlighting therapeutic targets currently under preclinical or clinical investigation. Notably, we evaluate recent advances in pharmacological and biomaterial-based interventions aimed at halting or reversing calcification, with a focus on their translational potential. By integrating mechanistic insights with therapeutic developments, this review offers a comprehensive perspective on VC pathophysiology and treatment, serving as a timely reference for future research and clinical innovation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.