Evidence map›Paper›PMID 41665674›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2026

Flexible intraoperative detectors for robotic and laparoscopic image-guided surgery: a systematic review.

G Pisano, M N van Oosterom, L J Slof, K Pirkovets, V A Ottens, T Buckle, H G van der Poel, F W B van Leeuwen

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G PisanoInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0001-9627-5065
M N van OosteromInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-0306-2568
L J SlofInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0009-0002-7897-8589
K PirkovetsInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.
V A OttensInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.
T BuckleInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands.ORCID 0000-0003-2980-6895
H G van der PoelDepartment of Urology, Netherlands Cancer Institute-Antoni Van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
F W B van LeeuwenInterventional Molecular Imaging Laboratory, Leiden University Medical Centre, Leiden, The Netherlands. f.w.b.van_leeuwen@lumc.nl.ORCID 0000-0002-6844-4025

Funding

NWO-KIC KICH1.ST03.21.030
6 · The paper itself

Abstract

purposeThis systematic review provides a comprehensive overview of flexible intraoperative detector technologies for robotic and laparoscopic image-guided surgery, with a focus on their clinical applications and impact. Additionally, it offers a perspective on future directions in the field.

methodsThe review was conducted according to PRISMA guidelines. A systematic search of PubMed and Google Scholar was performed up to June 2024 and updated through May 2025. Of 539 records initially identified, 90 studies met the inclusion criteria after screening and full-text assessment.

resultsOf the included studies, 61 involved human applications. Flexible detectors were classified into ultrasound (n = 29), radioactivity (gamma and beta, n = 38), optical (n = 19: fluorescence, endomicroscopy, Raman), and miscellaneous technologies (n = 4). Flexible ultrasound and radioactivity probes were the most employed in clinical settings, they were shown to enhance intraoperative dexterity with equivalent performance to conventional rigid probes. They enabled previously unfeasible procedures, such as robotic PSMA-targeted radioguided surgery. In contrast, optical and miscellaneous probes, though applied in human studies, remain largely at an early or conceptual stage, with limited demonstration of direct clinical impact.

conclusionFlexible sensing technologies offer advantages in size, flexibility, ergonomics, and integration with robotic platforms, enabling and/or improving image-guided surgery within the field of minimally-invasive interventions. The ultrasound and radioactivity ones showed the strongest utility, while optical and miscellaneous require further clinical evaluation. Overall, broader clinical adoption requires more rigorous, prospective trials to establish their efficacy and impact on surgical performance and outcomes.

Indexed as

LaparoscopyRobotic Surgical ProceduresSurgery, Computer-AssistedHumansDrop-in probesFlexible detectorsImage-guided surgeryMinimally invasive surgeryMolecular imagingRobotic surgery

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.