Evidence map›Paper›PMID 41665654›Full record

ArticleActa diabetologica2026

A gene expression study suggests the possible involvement of IGF2BP2-related ncRNA network in Type 2 Diabetes.

Andrea Latini, Chiara Morgante, Giada De Benedittis, Francesca Amati, Davide Lauro, Giuseppe Novelli, Cinzia Ciccacci, Vincenza Spallone, Paola Borgiani

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Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Andrea LatiniUniCamillus, Saint Camillus International University of Health Sciences, 00131, Rome, Italy.
Chiara MorganteDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Giada De BenedittisDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy. dbngdi01@uniroma2.it.ORCID http://orcid.org/0000-0001-9200-2510
Francesca AmatiDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Davide LauroDepartment of Systems Medicine, Endocrinology Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Giuseppe NovelliDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Cinzia CiccacciUniCamillus, Saint Camillus International University of Health Sciences, 00131, Rome, Italy.
Vincenza SpalloneDepartment of Systems Medicine, Endocrinology Section, University of Rome Tor Vergata, 00133, Rome, Italy.
Paola BorgianiDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.

Funding

MUR-PNRR M4-C2-I1.3 PE6 project PE00000019 Heal Italia
6 · The paper itself

Abstract

aimsGenome-wide association studies (GWAS) have identified the IGF2BP2 (Insulin-like Growth Factor 2 mRNA binding protein 2) gene as a susceptibility locus for Type 2 diabetes mellitus (T2D). This study aimed to evaluate the IGF2BP2 mRNA levels in the blood of a cohort of T2D patients and to quantify the expression levels of non-coding RNAs (ncRNAs) that are predicted to interact with it.

methodsWe extracted RNA from peripheral blood mononuclear cells of 50 T2D patients and 30 healthy controls (CTRL) and quantified, by qPCR, the IGF2BP2 expression levels. Using bioinformatics tools, we predicted its main ncRNAs target and quantified it.

resultsThe expression study showed a significantly higher IGF2BP2 level in T2D subjects than in CTRL. In silico analysis identified hsa-let7b-5p as a potential microRNA regulator of IGF2BP2, with reduced expression levels observed in T2D patients. Additionally, three lncRNAs (SNHG5, HOTAIR, and MEG3) were predicted as potential targets of IGF2BP2. Their expression levels were significantly elevated in T2D patients. In vitro assays demonstrated that inhibiting hsa-let7b-5p in HeLa cells resulted in increased expression of IGF2BP2 and the three lncRNAs.

conclusionThese findings highlight a potential regulatory network involving IGF2BP2, hsa-let7b-5p, and lncRNAs. This network may contribute to dysregulation of insulin/IGF signaling and glucose metabolism pathways, providing insights into T2D pathogenesis.

Indexed as

Diabetes Mellitus, Type 2RNA-Binding ProteinsRNA, UntranslatedAgedFemaleGene Expression RegulationGene Regulatory NetworksHeLa CellsHumansLeukocytes, MononuclearMaleMicroRNAsMiddle AgedRNA, Long NoncodingIGF2BP2 protein, humanMicroRNAsmirnlet7 microRNA, humanRNA-Binding ProteinsRNA, Long NoncodingRNA, UntranslatedIGF2BP2lncRNAsType 2 diabetes

Identifiers

PMID41665654

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.