Evidence map›Paper›PMID 41665491›Full record

ArticleeLife2026

Bryanna Isela-Inez Canales, Hunter O King, Peter W Reddien

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

3 authors.

Bryanna Isela-Inez CanalesWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID https://orcid.org/0000-0002-0693-3632
Hunter O KingWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID https://orcid.org/0009-0001-9823-1856
Peter W ReddienWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID https://orcid.org/0000-0002-5569-333X

Funding

Stem cell and regeneration regulatory mechanisms in planariansR35GM145345 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI PETER REDDIEN · 2022 to 2026
$2.4M
Eleanor Schwartz Charitable Foundation grantHoward Hughes Medical Institute InvestigatorNIGMS NIH HHS R35 GM145345NIH HHS R35 GM145345
6 · The paper itself

Abstract

Planarian regeneration and tissue turnover involve fate specification in pluripotent stem cells called neoblasts. Neoblasts select fates through the expression of fate-specific transcription factors, generating specialized neoblasts. Specialized neoblasts are spatially intermingled and can be dispersed broadly, frequently being present far from their target tissue. The post-mitotic progeny of neoblasts, serving as progenitors, can migrate and differentiate into mature cell types. Pattern formation is thus strongly influenced by the migratory assortment and differentiation of fate-specified progenitors in precise locations, which we refer to as progenitor targeting. This central step of pattern maintenance and formation, however, is poorly understood. Here, we describe a requirement for the conserved

Indexed as

Cell DifferentiationMAP Kinase Kinase Kinase 1PlanariansStem CellsAnimalsCell MovementRegenerationRNA InterferenceMAP Kinase Kinase Kinase 1developmental biologydifferentiationmap3k1neoblastplanarianprogenitorregenerationstem cell

Identifiers

PMID41665491
PMCPMC12890251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.