Evidence map›Paper›PMID 41665373›Full record

ArticleMicrobiology spectrum2026

Diagnostic utility of quantitative interferon-gamma release assays in elderly patients with tuberculosis.

Yoshikazu Mutoh, Yusuke Minato, Yuya Kawamoto, Shogo Hanai, Takumi Umemura, Hiroko Suzuki, Yuta Nishina, Kaho Hiramitsu, Seiya Ichihara, Satoshi Hagimoto and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoshikazu MutohDepartment of Infectious Diseases, Tosei General Hospital, Seto, Aichi, Japan.ORCID 0000-0002-7368-3004
Yusuke MinatoDivision of Anti-Infective Drug Discovery, Center for Infectious Disease Research, Fujita Health University, Toyoake, Aichi, Japan.ORCID 0000-0002-0888-8564
Yuya KawamotoDepartment of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Shogo HanaiDepartment of Infectious Diseases, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Takumi UmemuraDepartment of Infection Control team, Tosei General Hospital, Seto, Aichi, Japan.
Hiroko SuzukiDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Yuta NishinaDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Kaho HiramitsuDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Seiya IchiharaDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Satoshi HagimotoDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Jun FukiharaDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Hajime SasanoDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Kensuke KataokaDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Tomoki KimuraDepartment of Respiratory Medicine and Allergy, Tosei General Hospital, Seto, Aichi, Japan.
Yohei DoiDepartment of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence regarding the diagnostic value of quantitative interferon-gamma release assay (IGRA) results in elderly populations is limited, and large-scale data for QuantiFERON-TB Gold Plus (QFT-Plus) are scarce. We evaluated QFT-Plus and T-SPOT.TB (T-SPOT) for distinguishing active tuberculosis (ATB) from latent infection (LTBI) in elderly individuals in Japan, a super-aged country. We conducted a retrospective, cross-sectional diagnostic accuracy study of patients ≥65 years who underwent IGRA testing between 2015 and 2024 at two hospitals: a tuberculosis referral center (QFT-Plus and T-SPOT) and a tertiary hospital (T-SPOT only). ATB was defined as microbiologically confirmed TB. Quantitative IGRA values were compared between ATB and LTBI in all patients and in IGRA-positive subsets. Receiver operating characteristic (ROC) curves assessed discriminatory performance. Among 10,745 elderly patients (ATB:

Indexed as

Interferon-gamma Release TestsLatent TuberculosisTuberculosisAgedAged, 80 and overCross-Sectional StudiesDiagnosis, DifferentialFemaleHumansMaleRetrospective Studiesdiagnosiselderlyinterferon-gamma release assayQuantiFERON-TB Gold PlusT-SPOT.TBtuberculosis

Identifiers

PMID41665373
PMCPMC12955447

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.