sic1 mutation leads to rDNA instability by partial duplication with SIR4.

Taichi Murai, Shuichi Yanagi, Yutaro Hori, Yoshio Yamamuro, Takehiko Kobayashi

Abstract read

In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Taichi MuraiLaboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Shuichi YanagiLaboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Yutaro HoriLaboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Yoshio YamamuroLaboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Takehiko KobayashiLaboratory of Genome Regeneration, Institute for Quantitative Biosciences (IQB), The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.ORCID 0000-0002-7990-3741

Funding

AMED JP21gm1110010Japan Society for the Promotion of Science 21H04761JST JPMJCR19S3SPRING JPMJSP2108

6 · The paper itself

Abstract

The ribosomal RNA gene cluster (rDNA) in Saccharomyces cerevisiae consists of about 150 tandem copies, making it a fragile site prone to copy number changes through recombination among the repeat. While extensive research has been conducted to understand the mechanisms for rDNA stability maintenance, the relationship between the stability maintenance of rDNA and other genomic regions remains unclear. In this study, we identified a mutant, sic1, that exhibited instability in both rDNA and chromosome IV (chr.IV). We revealed that Ty element-mediated ectopic recombination leads to partial duplication and elongation of chr.IV. Furthermore, we found that rDNA instability is caused by an increased SIR4 gene dosage resulting from this partial duplication. These findings suggest a link between the stability of rDNA and other genomic regions.

Indexed as

DNA, RibosomalGene DuplicationGenomic InstabilitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeChromosomes, FungalGene DosageMutationRecombination, GeneticDNA, RibosomalSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiae

Identifiers

PMID41665005

DOI10.1093/nar/gkag096

PMCPMC12887534

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.