Evidence map›Paper›PMID 41664914›Full record

ArticleThe Journal of physiology2026

The pyrogenic mediator prostaglandin E

Takaki Yahiro, Yoshiko Nakamura, Kazuhiro Nakamura

Abstract read
In one paragraph

Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Takaki YahiroDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0001-7396-5442
Yoshiko NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-3491-0825
Kazuhiro NakamuraDepartment of Integrative Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-6095-8996

Funding

Japan Agency for Medical Research and Development JP25gm1910003Ministry of Education, Culture, Sports, Science and Technology of Japan JP20H03418Ministry of Education, Culture, Sports, Science and Technology of Japan JP21K06767Ministry of Education, Culture, Sports, Science and Technology of Japan JP23H00398Ministry of Education, Culture, Sports, Science and Technology of Japan JP25K10154Moonshot R&D JPMJMS2023Takeda Science Foundation
6 · The paper itself

Abstract

Seeking warmth during infection is a sickness behaviour that contributes to the development of fever and is often accompanied by chills. However, the central mechanism underlying this behaviour remains unknown. We recently reported two ascending thermosensory neuronal pathways from the lateral parabrachial nucleus (LPB) of the pons that drive thermoregulatory behaviours in hot and cold environments: one pathway to the preoptic area (POA), a thermoregulatory centre, mediates heat avoidance, whereas the other to the central amygdaloid nucleus (CeA), a limbic emotion centre, mediates cold avoidance. Here we investigated the role of prostaglandin E

Indexed as

Body Temperature RegulationDinoprostoneNeuronsParabrachial NucleusReceptors, Prostaglandin E, EP3 SubtypeAnimalsCold TemperatureMalePreoptic AreaRatsDinoprostoneReceptors, Prostaglandin E, EP3 Subtypeamygdalabehaviourchillsemotionfeverprostaglandinsomatosensory systemsthermoregulation

Identifiers

PMID41664914
PMCPMC12953009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.