Evidence map›Paper›PMID 41664846›Full record

ArticleJournal of periodontal research2026

Molar-Incisor and Generalized Grade C Periodontitis: Distinct Microbiome-Immune Interactions Suggest Divergent Pathogenesis.

Camila S Stolf, Hélvis E S Paz, Murilo C Paraluppi, Manuela M V Miguel, Mauro P Santamaria, Mabelle F Monteiro, Deyvid E Amgarten, Raquel R A Franco, Luciana S Branco-de-Almeida, Luciana M Shaddox and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Camila S StolfDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-5125-2326
Hélvis E S PazDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.
Murilo C ParaluppiDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-9192-1686
Manuela M V MiguelDepartment of Oral Health Practice and Center of Oral Health Research, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.
Mauro P SantamariaDepartment of Oral Health Practice and Center of Oral Health Research, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0001-9468-0729
Mabelle F MonteiroDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-9333-4349
Deyvid E AmgartenFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Raquel R A FrancoFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Luciana S Branco-de-AlmeidaDepartment of Dentistry II, Federal University of Maranhão, São Luís, Brazil.ORCID https://orcid.org/0000-0001-6928-8522
Luciana M ShaddoxDepartment of Oral Health Practice and Center of Oral Health Research, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0003-0948-1667
Renato C V CasarinDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-1037-591X

Funding

Mechanisms and Treatment Response of Aggressive Periodontitis in ChildrenR01DE019456 · NIDCR · UNIVERSITY OF FLORIDA · PI AUKHIL, IKRAMUDDIN, SHADDOX, LUCIANA MACCHION · 2009 to 2018
$5.6M
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/14430-3NIDCR NIH HHS R01 DE019456NIDCR NIH HHS R01DE019456
6 · The paper itself

Abstract

aimMolar-Incisor (PerioC-MIP) and Generalized (PerioC-G) Grade C Periodontitis could have distinctive etiopathogenesis behind their unique clinical patterns. Thus, this study aimed to distinguish these two phenotypes by analyzing the subgingival metagenomic profile and the inflammatory markers levels.

methodsIn this cross-sectional comparative study, Gingival Crevicular Fluid (GCF) and Subgingival Biofilm (SB) were collected from 18 PerioC-MIP North Americans and 14 periodontally healthy controls (HC) from the same location (HC-MIP) and 20 PerioC-G Brazilians and 20 controls (HC-G). From GCF, immunoenzymatic analysis was performed. SB functional and taxonomic bacterial content was determined using shotgun metagenomics sequencing.

resultsTaxonomic results showed significantly different alpha- and beta-diversity profiles between disease groups (p < 0.05). Aggregatibacter actinomycetemcomitans and Streptococcus sanguinis were associated with PerioC-MIP; levels of Tannerella forsythia, Filifactor alocis, Porphyromonas gingivalis, Fretibacterium fastidiosum, and Treponema denticola were significantly enriched at PerioC-G (p < 0.05). PerioC-G had the function for flagellar assembly enriched, while PerioC-MIP SB was associated with biofilm formation of Escherichia coli. Different GCF inflammatory marker levels for each pattern resulted in PerioC-G presenting higher levels of IL-1β, IL-6, and IL-10 than PerioC-MIP (p < 0.05).

conclusionPerioC-G and PerioC-MIP presented different taxonomical profiles and GCF cytokine levels, raising the hypothesis that they may represent two different stages/susceptibility patterns of Periodontitis Grade C.

Indexed as

MicrobiotaPeriodontitisAdultBiofilmsCross-Sectional StudiesCytokinesEubacterialesFemaleGingival Crevicular FluidHumansMaleMiddle AgedTannerella forsythiaTreponema denticolaCytokinesaggressive periodontitisinflammation mediatorsmetagenomephenotypevirulence factors

Identifiers

PMID41664846
PMCPMC13540801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.