Evidence map›Paper›PMID 41664840›Full record

ArticleImmunology2026

Resilient Biophysical Phenotype of Memory CD4

Aldo Abarca-Ortega, Blanca González-Bermúdez, Judith Félix-Escalera, Mónica González-Sánchez, Enzo Brito, Mónica De la Fuente, Gustavo R Plaza

Abstract read
In one paragraph

Article in Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aldo Abarca-OrtegaDepartamento de Ingeniería Mecánica, Universidad de Santiago de Chile, Santiago de Chile, Chile.ORCID 0000-0002-1600-8555
Blanca González-BermúdezCenter for Biomedical Technology, Universidad Politécnica de Madrid, Pozuelo de Alarcón, Spain.
Judith Félix-EscaleraDepartment of Genetics, Physiology and Microbiology. Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain.
Mónica González-SánchezDepartment of Genetics, Physiology and Microbiology. Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain.
Enzo BritoDepartamento de Ingeniería Mecánica, Universidad de Santiago de Chile, Santiago de Chile, Chile.
Mónica De la FuenteDepartment of Genetics, Physiology and Microbiology. Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Madrid, Spain.
Gustavo R PlazaCenter for Biomedical Technology, Universidad Politécnica de Madrid, Pozuelo de Alarcón, Spain.ORCID 0000-0002-5555-5498

Funding

Chilean National Agency for Research and Development 11251174Comunidad de Madrid TEC-2024/TEC-158European Commission 10113612Spanish Ministry of Science, Innovation and Universities PID2024-158773OB-I00
6 · The paper itself

Abstract

Age-related alterations in the immune system-collectively known as immunosenescence-include both quantitative and qualitative changes across various immune cell populations, including B cells, natural killer cells and T lymphocytes, affecting their structure, phenotype and function. While these changes have been characterised biochemically and physiologically, their biophysical manifestations remain less understood, particularly in individuals that achieve exceptional longevity. Here, we investigate the mechanical and structural properties of memory CD4

Indexed as

AgingCD4-Positive T-LymphocytesImmunologic MemoryImmunosenescenceLongevityMemory T CellsAnimalsCell MovementCytoskeletonFemaleMiceMice, Inbred C57BLPhenotypebiophysical properties of cellsCD4immunosenescencemechanobiologyT cell

Identifiers

PMID41664840
PMCPMC13135885

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.