Evidence map›Paper›PMID 41664822›Full record

ArticleNeuro-oncology advances

On the value of microsurgical resection compared to biopsy in elderly glioblastoma patients: A retrospective multicenter analysis and scoring system proposal.

Johannes P Pöppe, Melanie Buchta, Matthias Demetz, Christian F Freyschlag, Johannes Kerschbaumer, Claudius Thomé, Harald Stefanits, Saskia Gahleitner, Andreas Gruber, Jürgen Steinbacher and 8 more

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Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Johannes P PöppeDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.
Melanie BuchtaDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.
Matthias DemetzDepartment of Neurosurgery, University Hospital Innbruck, Medical University of Innsbruck, Innsbruck, Austria.
Christian F FreyschlagDepartment of Neurosurgery, University Hospital Innbruck, Medical University of Innsbruck, Innsbruck, Austria.
Johannes KerschbaumerDepartment of Neurosurgery, University Hospital Innbruck, Medical University of Innsbruck, Innsbruck, Austria.
Claudius ThoméDepartment of Neurosurgery, University Hospital Innbruck, Medical University of Innsbruck, Innsbruck, Austria.
Harald StefanitsDepartment of Neurosurgery, University Hospital Innbruck, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-4773-9801
Saskia GahleitnerDepartment of Neurosurgery, Johannes Kepler University Linz, Austria.
Andreas GruberDepartment of Neurosurgery, Johannes Kepler University Linz, Austria.ORCID https://orcid.org/0000-0002-0102-1765
Jürgen SteinbacherDepartment of Neuroradiology, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.
Lukas MacheggerDepartment of Neuroradiology, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.
Martin GeroldingerResearch Programme Biomedical Data Science, Paracelsus Medical University Salzburg, Austria.
Georg ZimmermannResearch Programme Biomedical Data Science, Paracelsus Medical University Salzburg, Austria.
Theo F J KrausInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.ORCID https://orcid.org/0000-0003-2944-5129
Karl SotlarInstitute of Pathology, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.
Miikka KorjaDepartment of Neurosurgery, University of Helsinki and Helsinki University Hospital, Finland.
Christoph J GriessenauerDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.
Christoph SchwartzDepartment of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Benefits of tumor resection in elderly glioblastoma multiforme (GBM) patients within the framework of multimodal treatment remains a matter of debate. This retrospective, multicenter analysis aims at the identification of patients who are most likely to benefit from microsurgical resection, and the development of a scoring system to improve future decision-making. Methods: Demographic and outcome data of GBM patients aged 65 years and older, who underwent resection or biopsy at three centers between 2003 and 2022, were analyzed. Frailty was assessed by the Modified 5-Item Frailty Index (mFI-5). Results: We studied 537 patients (median age 73.4 years); 369 (68.7%) underwent resection and 168 (31.3%) underwent biopsy. Resected patients were younger, were preoperatively more commonly functionally independent, were less frail, and had larger tumor volumes (all Conclusions: Selected elderly glioblastoma patients might benefit from microsurgical resection. A score to guide neurosurgical treatment decision-making and patient counseling was developed.

Indexed as

biopsyelderlyglioblastomaresectionscoring system

Identifiers

PMID41664822
PMCPMC12883206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.