ReviewCureus2026
Centering Ability and Canal Transportation of Nickel-Titanium (NiTi) Single-File Systems With and Without Glide Path in Extracted Natural Teeth: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Establishing an endodontic glide path is crucial for the preservation of tooth structure and helps to avert various iatrogenic errors, including perforations and instrument fracture. Whether the preparation of the glide path is required before shaping the canals is still debatable. This systematic review aims to assess the centering ability and canal transportation of single-file nickel-titanium (NiTi) instruments with and without glide path in extracted natural teeth. The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. An electronic database search using PubMed, SCOPUS, EMBASE, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Cochrane Library, Google Scholar, and grey literature was performed from inception till August 2025 based on the inclusion and exclusion criteria, and the quality was assessed using the revised Quality Assessment Tool for In Vitro Studies (QUIN) risk of bias tool. Three articles were included for the qualitative synthesis, and two articles were included for the meta-analysis. The results stated that there is less canal transportation and an increased centering ratio in the coronal, middle, and apical third of the canal when glide path preparation was done (p<0.05). The current systematic review provides evidence suggesting that centering ability is significantly higher and canal transportation is significantly lower for NiTi single-file systems when used after glide path preparation as compared to instrumentation without glide path preparation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.