ArticleCureus2026
Hypercobalaminemia Leading to the Diagnosis of Retroperitoneal Paraganglioma: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with heterogeneous clinical presentations, ranging from classic catecholamine-related symptoms to incidental imaging findings. Hypercobalaminemia is most commonly associated with hematologic disorders, liver disease, or solid malignancies, and has been described in association with neuroendocrine tumors; however, a specific association with PPGLs has not been previously reported. We describe the case of a 47-year-old normotensive woman referred for evaluation of persistently elevated serum vitamin B12 levels. Apart from intermittent abdominal discomfort, she was otherwise asymptomatic. After exclusion of common causes of hypercobalaminemia, abdominal imaging revealed a retroperitoneal para-aortic mass. Histopathological and immunohistochemical analyses were consistent with PPGLs, and biochemical testing demonstrated elevated plasma and urinary normetanephrine levels, supporting the diagnosis of a functioning paraganglioma.
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